Dementia in Parkinson Disease

The purpose of this study is to use a brain imaging method called PIB PET and VAT PET to
determine dementia subtypes in patients with Parkinson disease (PD). The ultimate goal of
this project is to be able to identify individuals with PD who are at risk of developing
dementia, and to distinguish the underlying cause of dementia. The investigators will be
including both PD and normal subjects in this study. This a long term study and we are
considering including a total of 320 participants in this protocol.

Inclusion Criteria:

- PD patients must exhibit three of the following cardinal signs: rest tremor, rigidity,
bradykinesia, or postural instability; or two of these features with one of the first
three displaying asymmetry.

Exclusion Criteria:

- history of head trauma, major neurological or psychiatric diseases other than
Parkinson disease and dementia, e.g. stroke, multiple sclerosis, depression or
schizophrenia.

- severe systemic diseases.

- inability to lie still for 90 minutes.

- metallic implants, pacemakers, or any other contraindication to MRI.

- refusal to consent to brain donation.