Minimizing the Utilization of Voiding Cystourethrography for Patients With Antenatal Hydronephrosis



Status:Recruiting
Conditions:Nephrology
Therapuetic Areas:Nephrology / Urology
Healthy:No
Age Range:Any - 5
Updated:11/8/2017
Start Date:July 27, 2016
End Date:June 2021
Contact:Nora Kern, M.D.
Email:NGL2Z@virginia.edu
Phone:434-924-0236

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It has previously been found that there is no correlation between degree of hydronephrosis
and presence of reflux; however this is oftentimes the criteria physicians use to obtain a
VCUG.

Investigators conducted a previous retrospective study to evaluate other possible findings on
ultrasound that may better predict reflux. Investigators found that if a postnatal ultrasound
showed any of the three findings of hydroureter, duplication or dysmorphic kidney, then the
odds ratio of detecting reflux was 8.07 (95%CI 3.86, 16.87). The purpose of this study is to
perform a randomized prospective study to validate this retrospective study. Investigators
hypothesis is that patients with hydronephrosis alone will be more likely to have negative
VCUG studies; hence obtaining a VCUG for this indication may not be warranted.

Inclusion Criteria:

- Patients with a history of antenatal hydronephrosis who have a post-natal ultrasound
demonstrating hydronephrosis alone and no other abnormalities

Exclusion Criteria:

- Patients with a post-natal ultrasound demonstrating bilateral hydronephrosis

- Patients with a history of posterior urethral valve or when a valve is suspected

- Patients who have hydronephrosis on ultrasound as well as other findings including
duplication, hydroureter, dysmorphic kidneys, or bladder abnormalities
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Charlottesville, Virginia 22908
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