TMS Modulation of Insula-related Brain Networks.02
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 2/17/2019 |
| Start Date: | December 2016 |
| End Date: | January 25, 2018 |
The purpose of this study is to investigate the modulatory effects of repetitive transcranial
magnetic stimulation (rTMS) on functional connectivity with the insula. Functional
connectivity (FC) measures the interaction between brain regions, and recent neuroimaging
studies have used FC to investigate how addiction affects FC among pertinent brain regions.
rTMS, which can excite cortical neurons, has shown promise as a method to manipulate brain
connectivity and could be used therapeutically to treat addiction. However, investigators
first need more information on brain FC and how it relates to behavior, in order to guide
rTMS target selection.
magnetic stimulation (rTMS) on functional connectivity with the insula. Functional
connectivity (FC) measures the interaction between brain regions, and recent neuroimaging
studies have used FC to investigate how addiction affects FC among pertinent brain regions.
rTMS, which can excite cortical neurons, has shown promise as a method to manipulate brain
connectivity and could be used therapeutically to treat addiction. However, investigators
first need more information on brain FC and how it relates to behavior, in order to guide
rTMS target selection.
Inclusion Criteria:
- generally healthy
- between the ages of 18-55
- right-handed
Exclusion Criteria:
- significant health problems (e.g., current and uncontrolled liver, lung, or heart
problems) or presence of medical illness likely to alter brain morphology (including
history of seizure, history of epilepsy in self or first degree relatives, stroke,
brain surgery, head injury, and known structural brain lesion)
- current diagnosis of Axis I psychiatric disorders (e.g., depression, anxiety disorder,
schizophrenia)
- meet DSM-5 criteria for current substance use disorder other than nicotine
- use of psychoactive medications that would result in a positive urine drug screen
- Current use of medications known to lower the seizure threshold
- positive breath alcohol concentration
- presence of conditions that would make MRI unsafe (e.g., metal implants, pacemakers)
- among women, a positive urine pregnancy test
- vision that cannot be corrected to 20/40
We found this trial at
1
site
Durham, North Carolina 27710
(919) 684-8111
Principal Investigator: Merideth A Addicott, PhD
Phone: 919-684-5237
Duke University Younger than most other prestigious U.S. research universities, Duke University consistently ranks among...
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