Providing Unique Support for Health (PUSH) Study
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 15 - 24 |
| Updated: | 11/9/2018 |
| Start Date: | August 1, 2017 |
| End Date: | June 30, 2021 |
| Contact: | Durryle D Brooks, PhD |
| Email: | dbrook2@jhmi.edu |
| Phone: | 443-287-4993 |
Identifying and Engaging Urban HIV Infected and Uninfected YBMSM in Care
Project Narrative This 3-city proposal seeks to address HIV disparities among young (ages
15-24) Black men who have sex with men (YBMSM) in a multilevel intervention to identify,
engage and retain, high-risk HIV-uninfected and HIV-infected urban YBMSM in the HIV
prevention and treatment cascade. The mobile-enhanced engagement intervention (MEI) is driven
by the expressed and self-determined needs of each HIV infected and uninfected participant
and includes care navigation, engagement, treatment and adherence. MEI also includes a
supplemental Screening, Brief Intervention, and Referral for Treatment (SBIRT), to support
YBMSM who face barriers accessing substance use treatment. By building upon existing case
management services and flexibility to be adapted across ages and maturity and for prevention
services, this intervention has the ability to transform networks, HIV and prevention care in
YBMSM in cities with very high primary and secondary HIV transmission.
15-24) Black men who have sex with men (YBMSM) in a multilevel intervention to identify,
engage and retain, high-risk HIV-uninfected and HIV-infected urban YBMSM in the HIV
prevention and treatment cascade. The mobile-enhanced engagement intervention (MEI) is driven
by the expressed and self-determined needs of each HIV infected and uninfected participant
and includes care navigation, engagement, treatment and adherence. MEI also includes a
supplemental Screening, Brief Intervention, and Referral for Treatment (SBIRT), to support
YBMSM who face barriers accessing substance use treatment. By building upon existing case
management services and flexibility to be adapted across ages and maturity and for prevention
services, this intervention has the ability to transform networks, HIV and prevention care in
YBMSM in cities with very high primary and secondary HIV transmission.
Project Summary the U.S. National HIV/AIDS Strategy 2020 calls for increasing access to care
and improving outcomes of people living with HIV and targeting biomedical prevention efforts
(including access to pre-exposure prophylaxis [PrEP]) where HIV is most heavily concentrated.
Baltimore, MD; Washington, DC; and Philadelphia, PA (BWP) are disproportionately burdened by
high rates of new cases of HIV infection, with disproportionate rates in young Black men who
have sex with men (YBMSM) aged 15-24. High incidence underscores the need for increased
identification, linkage and initiation in HIV and preventive care for YBMSM. Grants focused
on high rates directly address NIH research priorities to reduce health disparities in the
incidence of HIV, in antiretroviral therapy (ART) outcomes or in high HIV prevalent or
high-risk areas.
This innovative proposal seeks to test, treat and retain YBMSM living in BWP along the
prevention and treatment continuum using the following aims:
Aim 1. Identify and recruit young (ages 15-24) Black men who have sex with men (YBMSM) in 3
urban cities who are (1) HIV-infected, not virally suppressed; and (2) high-risk
HIV-uninfected YBMSM, including gender variant and questioning men, using respondent driven
sampling (RDS) with targeted seed identification; Aim 2. Compare the efficacy of two study
arms (mobile-enhanced engagement intervention (MEI) vs. standard of care (SOC)) to achieve
sustained retention (measured by ≥ 4 follow up visits per 18-months) and engagement in HIV
care (measured by durable viral suppression (HIV VL < 200 copies/ml) and substance treatment
among 240 HIV-infected YBMSM who are not virally suppressed and recruited from RDS; and Aim
3. Modify and implement mobile-enhanced intervention for 225 high-risk HIV-uninfected YBMSM,
recruited from RDS to promote linkage, retention and engagement of pre-exposure prophylaxis
(PrEP) and substance treatment uptake over 12-months, comparing younger (15-19) and older
(20-24) participants.
and improving outcomes of people living with HIV and targeting biomedical prevention efforts
(including access to pre-exposure prophylaxis [PrEP]) where HIV is most heavily concentrated.
Baltimore, MD; Washington, DC; and Philadelphia, PA (BWP) are disproportionately burdened by
high rates of new cases of HIV infection, with disproportionate rates in young Black men who
have sex with men (YBMSM) aged 15-24. High incidence underscores the need for increased
identification, linkage and initiation in HIV and preventive care for YBMSM. Grants focused
on high rates directly address NIH research priorities to reduce health disparities in the
incidence of HIV, in antiretroviral therapy (ART) outcomes or in high HIV prevalent or
high-risk areas.
This innovative proposal seeks to test, treat and retain YBMSM living in BWP along the
prevention and treatment continuum using the following aims:
Aim 1. Identify and recruit young (ages 15-24) Black men who have sex with men (YBMSM) in 3
urban cities who are (1) HIV-infected, not virally suppressed; and (2) high-risk
HIV-uninfected YBMSM, including gender variant and questioning men, using respondent driven
sampling (RDS) with targeted seed identification; Aim 2. Compare the efficacy of two study
arms (mobile-enhanced engagement intervention (MEI) vs. standard of care (SOC)) to achieve
sustained retention (measured by ≥ 4 follow up visits per 18-months) and engagement in HIV
care (measured by durable viral suppression (HIV VL < 200 copies/ml) and substance treatment
among 240 HIV-infected YBMSM who are not virally suppressed and recruited from RDS; and Aim
3. Modify and implement mobile-enhanced intervention for 225 high-risk HIV-uninfected YBMSM,
recruited from RDS to promote linkage, retention and engagement of pre-exposure prophylaxis
(PrEP) and substance treatment uptake over 12-months, comparing younger (15-19) and older
(20-24) participants.
Inclusion Criteria:
- Assigned male at birth
- 15-24 years old
- English speaking
- Black/African American
- Hispanic/Latino ethnicity
- HIV positive, viral load of 200 or greater
- HIV negative, at high risk of HIV acquisition
- Sex with another male within last 12-months
- No plans to move outside of the research catchment area in next 18-months
- Able and willing to provide informed consent
- Not currently taking pre-exposure prophylaxis (PrEP)
- Not currently enrolled or planning to enrolled in an HIV vaccine trial
- Not currently enrolled or planning to enroll in an HIV adherence intervention
Exclusion Criteria:
- Birth-identified female
- under age 15
- Over age 24
- Non-English speaking
- No sex with another male in prior 12-months
- Not Black/African American or Hispanic identified
- HIV-positive, virally suppressed
- HIV-negative, not at high risk of HIV acquisition
- Unable or unwilling to provide consent for study participation
- Unable or unwilling to return for study visits
- Unwilling to provide an oral, blood or urine specimen for testing
- Currently taking pre-exposure prophylaxis (PrEP)
- Active or previous participation in an HIV vaccine trial
- Current participation in an adherence intervention (unless proof in the
non-intervention arm)
- plan to relocate out of Baltimore, Washington DC, or Philadelphia in next 18- months
We found this trial at
1
site
200 North Wolfe Street
Baltimore, Maryland 21287
Baltimore, Maryland 21287
Principal Investigator: Renata Arrington-Sanders, MD, ScM, MPH
Phone: 443-287-4993
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