Intrathecal Chloroprocaine vs. Bupivacaine for Cervical Cerclage
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - 45 |
| Updated: | 11/8/2017 |
| Start Date: | October 13, 2017 |
| End Date: | October 2018 |
| Contact: | Dan Drzymalski, MD |
| Email: | ddrzymalski@tuftsmedicalcenter.org |
| Phone: | (617) 636-6044 |
A Randomized Controlled Clinical Trial of Intrathecal Chloroprocaine vs. Bupivacaine for Cervical Cerclage
This study aims to compare the effect of chloroprocaine vs. bupivacaine on duration of motor
block and duration until meeting discharge criteria in patients undergoing cervical cerclage.
The hypothesis is that chloroprocaine will result in faster resolution of motor block.
block and duration until meeting discharge criteria in patients undergoing cervical cerclage.
The hypothesis is that chloroprocaine will result in faster resolution of motor block.
Cervical cerclage is an ambulatory surgical procedure of short duration commonly performed
under spinal anesthesia. Bupivaciane and chlororpocaine are both commonly used, but how their
use impacts clinical care, in particular patient flow, is not well studied.
This is a prospective, randomized, double blind, controlled trial. Participants meeting
inclusion criteria will be randomly allocated to receive spinal anesthesia with either
chloroprocaine or bupivacaine.
Patients will then be assessed for motor block and sensory level until they are discharged
from the recovery room.
under spinal anesthesia. Bupivaciane and chlororpocaine are both commonly used, but how their
use impacts clinical care, in particular patient flow, is not well studied.
This is a prospective, randomized, double blind, controlled trial. Participants meeting
inclusion criteria will be randomly allocated to receive spinal anesthesia with either
chloroprocaine or bupivacaine.
Patients will then be assessed for motor block and sensory level until they are discharged
from the recovery room.
Inclusion Criteria:
- ASA classification II or III females
- Age: 18-45 years old
- BMI ≤ 50 kg/m2
- Singleton pregnancy
- Simple prophylactic cervical cerclage
- Planning neuraxial anesthesia
Exclusion Criteria:
- Abdominal and complex cervical cerclage (e.g. bulging bag)
- Contraindication to neuraxial anesthesia
- Known hypersensitivity to chloroprocaine (a.k.a. Ester allergy), paraaminobenzoic acid
(PABA) or bupivacaine (a.k.a. Amide allergy)
- Pseudocholinesterase deficiency
- Concomitant use with ergot-type oxytocic drugs
We found this trial at
1
site
800 Washington St
Boston, Massachusetts 02111
Boston, Massachusetts 02111
(617) 636-5000
Phone: 617-636-6044
Tufts Medical Center Tufts Medical Center is an internationally-respected academic medical center – a teaching...
Click here to add this to my saved trials
