Combination Study of Capecitabine and Erlotinib Concurrent With Radiotherapy for Non-Operable Advanced Pancreatic Cancer

Over the past several decades, 5-fluorouracil based chemoradiation has been the cornerstone
for the treatment of locally advanced non-operable pancreatic cancer. However, the survival
of these patients is disappointing. The majority of the patients suffer either local
progression or metastatic disease. With the availability of Capecitabine, a few pilot studies
showed the the drug is convenient, tolerable and safe in combination with radiation therapy.
Capecitabine demonstrated its superior anti-tumor activity with 14 months of median survival.
However, these are small Phase I studies and the survival benefit needs to be further
validated with larger studies. Epidermal growth factor receptor (EGFR) has been implicated in
tumor growth and angiogenesis. Inhibiting EGFR by Tarceva has demonstrated effective
treatment in metastatic pancreatic cancer. Anti-epidermal growth factor therapy in
combination with radiotherapy has been demonstrated efficacious in other solid tumors such as
head and neck cancer. We hypothesize that the combination of Tarceva and Capecitabine has
synergistic anti-tumor effect. Hence, improvement of median survival could be potentially
achieved with this novel combination.

Inclusion Criteria:

- Histologic or cytologic diagnosis of adenocarcinoma of the pancreas that is locally
advanced & not amenable to resection with curative intent.

- Must not have received prior systemic therapy for locally advanced disease.

- ECOG performance status must be 0-2.

- Adequate hepatic, renal & bone marrow function.

- Radiographic evidence of disease is required.

- Life expectancy > 12 weeks.

Exclusion Criteria:

- Prior treatment with Capecitabine & other EGFR inhibitor.

- Patients with GI tract disease resulting in an inability to take oral medications.

- Significant GI disorders with diarrhea as a major symptom.

- Uncontrolled intercurrent illness including active infection,symptomatic congestive
heart failure, unstable angina pectoris, cardiac arrhythmias now well controlled with
medication, myocardial infarction within the previous 6 months, psychiatric
illness/social situations that would limit compliance with study requirements.

- Patients with metastases.

- Patients who have had chemotherapy.

- Patients may not be receiving any other investigational agents, or have participated
in any investigational drug study.

- Extensive symptomatic fibrosis of the lungs.

- Females who are pregnant or lactating.

- History of any other malignancy in the last 2 years, except prior history of in situ
cancer, basal or squamous cell skin cancer are eligible.

- Known DPD deficiency.

- Receiving therapeutic doses of Coumarin-derivative anticoagulant therapy. Patients
requiring anticoagulation who may be safely switched to LMWH are eligible.