Extracorporeal Filtration of Subarachnoid Hemorrhage Via Spinal Catheter

Inclusion Criteria:

- Age: 18 years or older

- Informed consent by the patient or his/her legally authorized representative

- Modified Fisher Grade 2, 3, or 4

- Hunt & Hess I-III

- First aneurysmal SAH that has been confirmed by Angio, CTA or MRA

- Patient is ≤ 48 hours post bleeding event

- World Federation of Neurosurgeons (WFNS) Grades I-IV and those Grade V patients who
improve to Grade IV or less after ventriculostomy.

Exclusion Criteria:

- Patients with a SAH due to mycotic aneurysm or AV malformation

- Patients who present with an acute MI or unstable angina

- Patients with uncontrolled diabetes

- Patients who present with a creatinine > 2.0mg/dl

- Imaging demonstrates supratentorial mass lesions greater than 50 cc

- Imaging demonstrates more than 5 mm of mid-line-shift associated with infarction and
or edema

- Effacement of the basilar cisterns (suprasellar, ambient, chiasmatic and
quadrageminal)

- Vasospasm on admission as defined by angiographic evidence

- Patients with a coagulopathy that cannot be reversed per the professional discretion
of the investigator

- Thrombocytopenia def. platelet count < 100,000

- Patients on low molecular weight heparin e.g., Lovenox

- Patients on Clopidogrel bisulfate (Plavix) or other chronic platelet inhibitors

- Patients with a documented history of cirrhosis

- Patients who will be managed with supportive care rather than intervention

- Obstructive hydrocephalus i.e., non-communicating

- Pregnancy

- History of posterior fusion hardware that would interfere with placement of the
catheter

- Pre-existing Lumbar Drain

- Local skin infections or eruptions over the puncture site

- Signs of systemic infection/sepsis or pneumonia

- Lumbar puncture within 6 hours

- Concurrent participation in another study which is not observational or retrospective
in nature without prior approval from the Sponsor