Pentosan Polysulfate Sodium and Meclofenamic Acid as Treatments in Patients With Psychotic Disorders

Chronic, low-grade brain inflammation is involved in the development of schizophrenia and
other psychotic disorders. Medications with anti-inflammatory properties, like meclofenamic
acid and pentosan polysulfate may help to reduce brain inflammation and serve as a treatment
of psychotic disorders.

Inclusion Criteria:

- Diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder,
bipolar I disorder, delusional disorder, other specified schizophrenia spectrum and
other psychotic disorders, unspecified schizophrenia spectrum and other psychotic
disorders

- Negative pregnancy test in females of childbearing age

Exclusion Criteria:

- Urine drug screen positive for psychostimulants such as cocaine, amphetamines and
ecstasy

- Any infection, neoplasm, autoimmune disease or other primary inflammatory condition
(3) Previous diagnosis of intellectual disability or dementia

- Current treatment with heparin

- Use of or allergy to non-steroidal anti-inflammatory agent or pentosan polysulfate
sodium

- Current or anticipated corticosteroid use

- History of peptic ulcer disease, gastro esophageal reflux disease, or gastrointestinal
bleeding

- Those on warfarin or any anticoagulant

- Current treatment with lithium or asthma medication

- Individuals with pre-existing liver, cardiac, or kidney disease