Turmeric and Curcumin on Sebum Production

Turmeric extracts and curcumin have been shown to be safe, even at high doses without
significant side-effects. Previous clinical studies in other inflammatory skin diseases have
shown that a dosage of curcumin at 6,000 mg daily was effective while lower doses were not.
In a human phase I clinical trial examining the effects of high dose curcumin in preventing
premalignant lesions, even curcumin doses as high as 8,000 mg/day resulted in no toxic
effects after 3 months. This study will involve participant ingestion of 6,000 mg/day of
turmeric or curcumin to assess how this affects their sebum production.

The investigators will also be collecting stool from the study subjects, and examining how
the curcumin and turmeric may modulate their gut microbiome. The investigators will
specifically be looking to see if curcumin or turmeric have any changes on the gut flora
towards bacteria that produce more short chain fatty acids. Certain bacteria that make up the
microbiome produce short chain fatty acids, such as butyrate and propionate, which have
demonstrated anti-inflammatory properties. Thus, it would be interesting to see if turmeric
or curcumin exert any of its anti-inflammatory effects via modulation of the microbiome.

Inclusion Criteria:

1. Age 18 to 50 years of age, and

2. Subject must be able to read and comprehend study procedures and consent forms.

Exclusion Criteria:

1. Subject should be generally healthy and have no smoking history in the past one year,
and must have no history of diabetes, metabolic syndrome, known cardiovascular
disease, malignancy, kidney disease, or chronic steroid use.

2. Those who used topical medications in the past two weeks or systemic antibiotics or
oral probiotics within one month of starting the study.

3. Subjects who are postmenopausal

4. Those who are pregnant or breastfeeding.

5. Those that are prisoners or cognitively impaired.

6. Those who have a known allergy to black pepper should not participate in this clinical
trial, since one of the treatments consists of tablets containing a small amount
(1.25mg/tablet) of black pepper.

7. Those that are taking angiotensin converting enzyme inhibitor medications or
angiotensin receptor blocker medications for any reason.