Phase II Umbrella Study of Novel Anti-cancer Agents in Patients With NSCLC Who Progressed on an Anti-PD-1/PD-L1 Containing Therapy.

This is an open-label, multi-centre, umbrella Phase II study in patients with metastatic
non-small cell lung cancer (NSCLC) who have progressed on an anti-programmed cell
death-1/anti-programmed cell death ligand 1 (anti-PD-1/PD-L1) containing therapy. This study
is modular in design, consisting of a number of treatment cohorts, allowing evaluation of the
efficacy, safety, and tolerability of multiple treatment arms. There is currently no
established therapy for patients who have received immune checkpoint inhibitors and
platinum-doublet therapies, and novel treatments are urgently needed.

This protocol has a modular design, with the potential for future treatment arms to be added
via protocol amendment.

Inclusion criteria:

- At least 18 years of age at the time of signing the informed consent form.

- Patient must have histologically or cytologically confirmed metastatic or locally
advanced and recurrent NSCLC which is progressing.

- Patients eligible for second- or later-line therapy, who must have received an
antiPD1/PD-L1 containing therapy and a platinum-doublet regimen for locally advanced
or metastatic NSCLC either separately or in combination. Prior durvalumab is
acceptable. The patient must have had disease progression on a prior line of
antiPD1/PD-L1 therapy.

- ECOG/WHO performance status of 0 to 1, and a minimum life expectancy of 12 weeks.

- Patient must have at least 1 lesion that can be accurately measured. A previously
irradiated lesion can be considered a target lesion if the lesion has clearly
progressed.

- Evidence of post-menopausal status or negative urinary or serum pregnancy test for
female pre-menopausal patients.

Exclusion Criteria:

- Patients whose tumour samples have targetable alterations in EGFR and/or ALK are
excluded. In addition, patients whose tumour samples are known to have targetable
alterations in ROS1, BRAF, MET or RET, are to be excluded.

- Active or prior documented autoimmune or inflammatory disorders.

- Active infection including hepatitis B (known positive HBV surface antigen [HBsAg]
result), hepatitis C, or human immunodeficiency virus (positive HIV 1/2 antibodies).

- Female patients who are pregnant or breastfeeding, or male or female patients of
reproductive potential who are not willing to employ effective birth control.

- Known allergy or hypersensitivity to any of the study drugs or any of the study drug
excipients.

- Patient has spinal cord compression or symptomatic brain metastases.

- Any concurrent chemotherapy, immunotherapy, biologic or hormonal therapy for cancer
treatment. Patients may receive treatment with bisphosphonates or receptor activator
of nuclear factor kappa-Β ligand (RANKL) inhibitors for the treatment of bone
metastases.