Vinorelbine in Treating Patients With Advanced Solid Tumors That Have Not Responded to Treatment and Liver Dysfunction

OBJECTIVES:

- To correlate indocyanine green and lidocaine metabolism with vinorelbine ditartrate
pharmacokinetics in patients with advanced, refractory solid tumors and varying degrees
of liver dysfunction.

- To determine the pharmacokinetics of vinorelbine ditartrate in these patients.

- To test a plan of dose adjustment for vinorelbine ditartrate administration in these
patients.

OUTLINE: Patients are stratified according to extent of clinical liver dysfunction (normal vs
mild vs moderate vs severe).

Patients receive dose-adjusted vinorelbine ditartrate IV over 10 minutes once weekly in the
absence of disease progression or unacceptable toxicity. Patients achieving an objective
complete response receive 2 additional courses of study therapy.

Patients undergo blood sample collection periodically during study for pharmacokinetic and
pharmacodynamic correlative studies. Blood is also collected after patients receive lidocaine
IV push and indocyanine green (ICG) IV push. Samples are analyzed for whole blood and plasma
concentrations of vinorelbine ditartrate and its metabolites by high performance liquid
chromatography (15) or by liquid chromatography/tandem mass spectrometry assay. Samples are
also analyzed for ICG clearance and lidocaine hydrochloride metabolic capacity by fluorescent
polarization immunoassay.

After completion of study therapy, patients are followed periodically.

DISEASE CHARACTERISTICS:

- Histologically confirmed advanced solid tumor

- Any histology allowed

- Refractory to standard therapy OR no standard therapy exists

- Previously untreated non-small cell lung cancer allowed, provided abnormal liver
function is present, defined as moderate (group 3) or severe (group 4)

- Measurable disease not required

- Present measurable disease requires baseline measurements within 4 weeks of study
entry

- Patients with acute hepatitis from viral or drug etiologies should recover to a stable
baseline prior to study therapy

- History of brain metastasis allowed, provided the following criteria are met:

- Metastasis has been controlled by radiotherapy or surgery

- Patient is not currently on corticosteroids

- Neurologic status is stable

PATIENT CHARACTERISTICS:

- Karnofsky performance status 70-100%

- Life expectancy ≥ 2 months

- ANC = 1,500/mm³

- Platelet count = 100,000/mm³

- Hemoglobin = 10 g/dL (transfusion to this level allowed)

- Creatinine < 1.5 mg/dL OR creatinine clearance > 60 mL/ min

- Patients with EKG evidence of first- or second-degree AV block or left or right bundle
branch block are ineligible for the lidocaine bolus, but may otherwise be treated on
this protocol

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

- No concurrent illness (e.g., cardiovascular, pulmonary, or central nervous system)
that is poorly controlled or of such severity that the investigator deems unwise to
enter the patient on protocol

- Must have ability to comply with study treatment and required tests

- Obstructive jaundice requires a drainage procedure prior to study treatment

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

- Recovered from prior therapy

- At least 3 weeks since prior chemotherapy (6 weeks for mitomycin or nitrosourea
therapy)

- No prior radiotherapy to > 30% of the bone marrow or more than standard adjuvant
pelvic radiotherapy for rectal cancer