Lung Volume Recruitment Combined With Expiratory Muscle Strength Training in ALS
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology, Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 5/9/2018 |
| Start Date: | March 1, 2018 |
| End Date: | December 2021 |
| Contact: | Valerie Ferment |
| Email: | alsresearch@umn.edu |
| Phone: | 612-301-1535 |
A Pilot Study of Lung Volume Recruitment Combined With Expiratory Muscle Strength Training in ALS
The purpose of this study is to investigate the effects of two treatment techniques called
Expiratory Muscle Strength Training (EMST) and Lung Volume Recruitment (LVR) on breathing,
swallowing, speech, and cough function in persons with mild to moderate ALS. Half of the
participants will do EMST alone, and the other half of the participants will do EMST and LVR.
Expiratory Muscle Strength Training (EMST) and Lung Volume Recruitment (LVR) on breathing,
swallowing, speech, and cough function in persons with mild to moderate ALS. Half of the
participants will do EMST alone, and the other half of the participants will do EMST and LVR.
Inclusion Criteria:
- ALS defined as possible, laboratory-supported probable, probable, or definite by El
Escorial criteria
- Reduced Maximal Expiratory Pressure (MEP) compared to norms for age and sex
- Forced Vital Capacity (FVC) > 65% predicted
Exclusion Criteria:
- Inability to provide informed consent
- Relative contraindications to LVR, including known pneumothorax, active internal
bleeding, unstable hypertension, unstable angina, emphysema, recent barotrauma, or
FEV1 (Forced Expiratory Volume, trial 1)/FVC ratio < 0.7.
- Use of EMST or breath stacking > 3 days/week within 12 weeks of screening
- Amyotrophic Lateral Sclerosis-Cognitive Behavioral Scale (ALS-CBS) score predictive of
dementia (≤ 10)
- Participation in another clinical trial of an intervention in ALS within 30 days of
study enrollment or during study enrollment
We found this trial at
2
sites
Gainesville, Florida 32610
(352) 392-3261
Principal Investigator: Emily Plowman, PhD
Phone: 352-273-8632
University of Florida The University of Florida (UF) is a major, public, comprehensive, land-grant, research...
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Minneapolis, Minnesota 55455
(612) 625-5000
Principal Investigator: David Walk, MD
Phone: 612-301-1535
Univ of Minnesota With a flagship campus in the heart of the Twin Cities, and...
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