A Study to Evaluate Pazopanib Tablets in Patients Who Have Neovascular Age-related Macular Degeneration

This is a multi-center, open label study of pazopanib administered for 28 days in adult
patients with subfoveal CNV due to neovascular AMD. The primary aim is to evaluate safety and
tolerability in patients with neovascular AMD and a secondary aim is to evaluate
pharmacokinetics and pharmacodynamics. This study does not include a control treatment group
(e.g. placebo or active comparator), and instead will be benchmarked to visual acuity and OCT
changes observed following treatment with other anti-angiogenic agents in a similar patient
population over the same treatment period.

All subjects will receive tablets administered once daily. Subjects will be screened within
eight days prior to treatment assignment and initiation of study treatment. The duration of
treatment will be 28 days, and subjects will participate in a baseline and four subsequent
weekly study visits during the treatment phase. Subjects will also return for a follow-up
visit approximately two weeks after last dose of study medication.

Inclusion Criteria:

- Age-related macular degeneration patients diagnosed with subfoveal choroidal
neovascularization in the study eye, with all of the following characteristics
required and confirmed by a central reading center:

- CNV caused by AMD that extends under the geometric center of the foveal avascular
zone

- CNV comprises ≥ 50% of lesion area

- Total lesion area no greater than 12 disc areas on fluorescein angiography, where
the lesion complex includes CNV, blood, blocked fluorescence not from blood, and
serous detachment of the retinal pigment epithelium

- classic CNV comprises <50% of the lesion area

- fibrosis comprises ≤ 25% of lesion area

- Center subfield > 320 microns on SD-OCT (inclusive of subretinal fluid)

- if no evidence of classic CNV, then presumed to have recent disease progression
because of deterioration (≥ 5 letter decrease in vision or evidence of growth of
a CNV lesion on fluorescein angiography ) within last 3 months or evidence of
hemorrhage from CNV

- Best-corrected ETDRS visual acuity score in the study eye of between 25 and 73 letters
(approximately equivalent to Snellen VA of 20/320 to 20/32) at screening.

- Male or female ≥ 50 years of age.

- A female subject is eligible to participate if she is of non-childbearing potential
defined as either pre-menopausal with a documented tubal ligation or hysterectomy, or
postmenopausal defined as 12 months of spontaneous amenorrhea. In questionable cases
of postmenopausal status a blood sample with simultaneous follicle stimulating hormone
(FSH) > 40 MlU/ml and estradiol < 40 pg/ml (<140 pmol/L) or value consistent with
local laboratory recommended value is confirmatory.

- Subject is willing and able to return for all study visits, and is willing and able to
comply with all protocol requirements and procedures.

- Subject is capable of giving written informed consent, which includes compliance with
the requirements and restrictions listed in the consent form. If the subject is unable
to read the consent form due to visual impairment then the consent must be read to the
subject verbatim by person administering the consent, a family member or legally
acceptable representative. (Note: Consent by legally acceptable representative is
allowed where this is in accordance with local laws, regulations and ethics committee
policy.)

- QTcF <450msec; or QTcF<480msec in subjects with Bundle Branch Block.

- AST, ALT, alkaline phosphatase and bilirubin ≤ 1.5xULN (isolated bilirubin >1.5xULN is
acceptable if bilirubin is fractionated and direct bilirubin <35%).

Exclusion Criteria:

- Additional eye disease in the study eye that could compromise best-corrected visual
acuity (e.g. glaucoma with documented visual field loss, clinically significant
diabetic retinopathy, ischemic optic neuropathy, infection or retinitis pigmentosa).

- CNV in the study eye due to other causes unrelated to age-related macular
degeneration.

- The presence of retinal angiomatous proliferation (RAP) in the study eye, as
determined by the investigator (confirmation by indocyanine green angiography is not
required).

- Geographic atrophy involving the center of the fovea in the study eye.

- Anterior segment and vitreous abnormalities in the study eye that would preclude
adequate observation of the fundus for photographs, fluorescein angiography and
SD-OCT.

- Vitreous, subretinal or retinal hemorrhage in the study eye that is unrelated to AMD.
Any previous treatment in the study eye for neovascular AMD, approved or
investigational.

- Current intravitreal anti-VEGF therapy in the fellow eye.

- Within 6 months prior to the Screening Visit, use of any systemically administered
anti-angiogenic agent (e.g., bevacizumab, sunitinib, cetuximab, sorafenib, pazopanib),
approved or investigational.

- Intraocular surgery in the study eye within 3 months of dosing.

- Aphakia or total absence of the posterior capsule (Yttrium aluminum garnet (YAG)
capsulotomy permitted) in the study eye.

- History of vitrectomy in the study eye.

- Presence of RPE tear in the study eye.

- Subject has uncontrolled glaucoma (intraocular pressure >25 mmHg) despite treatment
with anti-glaucoma medication.

- Within 6 months prior to the Screening Visit, use of medications known to be toxic to
the retina, lens or optic nerve (e.g. desferoximine, chloroquine/hydrochloroquine,
chlorpromazine, phenothiazines, tamoxifen, nicotinic acid, and ethambutol).

- Use of systemic steroids (>10 mg prednisone or equivalent/day) within 14 days of first
dose.

- A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody
result within 3 months of screening.

- Current or chronic history of liver disease, or known hepatic or biliary abnormalities
(with the exception of Gilbert's syndrome or asymptomatic gallstones).

Medical history or unresolved medical condition, for example:

- Uncontrolled Diabetes Mellitus, with hemoglobin A1c (HbA1c) > 10%

- Myocardial infarction or stroke within 6 months of screening

- Active bleeding disorder

- Major surgery within 3 months of screening

- Hepatic impairment

- Clinically relevant thyroid disease

- Uncontrolled hypertension, based on criteria provided in Section 4.4.1.2.

- Subject has a history within the past 2 years of alcohol, substance abuse, or
psychiatric disorder likely to confound the efficacy or safety assessments. A
history of known HIV infection.

- Use of prohibited medications listed in Section 9.2 within the restricted
timeframe relative to the first dose of study medication.

- History of sensitivity to any of the study medications, or components thereof or
a history of drug or other allergy that, in the opinion of the investigator or
GSK Medical Monitor, contraindicates their participation.

- A condition or situation, which, in the opinion of the investigator, may result
in significant risk to the patient, confound the study results or interfere
significantly with participation.

- History of sensitivity to any of the study medications, or components thereof or
a history of drug or other allergy that, in the opinion of the investigator or
GSK Medical Monitor, contraindicates their participation.