A Phase 2 Study Evaluating The Efficacy And Safety Of PF 04494700 In Mild To Moderate Alzheimer's Disease



Status:Completed
Conditions:Alzheimer Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:50 - Any
Updated:12/2/2018
Start Date:December 2007
End Date:December 2010

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Trial Summary
Trial Overview
Inclusion Criteria

A Double Blind, Placebo Controlled, Randomized, Multicenter Study Evaluating The Efficacy And Safety Of Eighteen Months Of Treatment With PF 04494700 (TTP488) In Participants With Mild To Moderate Alzheimer's Disease

The purpose of this study is to evaluate the efficacy and safety of PF 04494700 in
participants with mild to moderate Alzheimer's disease.


Inclusion Criteria:

- Mini Mental State Exam (MMSE) score between 14-26 (inclusive) at screening.

- Participants must be receiving acetylcholinesterase inhibitors on a stable dose for at
least 4 months prior to randomization

Exclusion Criteria:

- Current evidence or history of neurological, psychiatric and any other illness that
could contribute to non-Alzheimer's dementia.

- Known history of familial AD or any evidence for early onset AD known or possibly
associated with genetic mutations.

- Evidence or history of diabetes mellitus Type 1 or Type 2.

- History or symptoms of autoimmune disorders.
We found this trial at
43
sites
Pfizer Investigational Site
Phoenix, Arizona 85016
1113
mi
from 98109
Phoenix, AZ
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Pfizer Investigational Site
Ann Arbor, Michigan 48109
1905
mi
from 98109
Ann Arbor, MI
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Pfizer Investigational Site
Atlanta, Georgia 30309
2177
mi
from 98109
Atlanta, GA
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Pfizer Investigational Site
Baltimore, Maryland 21234
2328
mi
from 98109
Baltimore, MD
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Pfizer Investigational Site
Beachwood, Ohio 44122
?
mi
from 98109
Beachwood, OH
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Pfizer Investigational Site
Boston, Massachusetts 02115
2485
mi
from 98109
Boston, MA
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Pfizer Investigational Site
Charleston, South Carolina 29425
2422
mi
from 98109
Charleston, SC
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Pfizer Investigational Site
Chicago, Illinois 60611
1733
mi
from 98109
Chicago, IL
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Pfizer Investigational Site
Dallas, Texas 75204
1680
mi
from 98109
Dallas, TX
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Pfizer Investigational Site
Grand Rapids, Michigan 49506
1797
mi
from 98109
Grand Rapids, MI
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Pfizer Investigational Site
Houston, Texas 77030
1892
mi
from 98109
Houston, TX
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Pfizer Investigational Site
Indianapolis, Indiana 46234
1858
mi
from 98109
Indianapolis, IN
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Pfizer Investigational Site
Irvine, California 92606
991
mi
from 98109
Irvine, CA
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Pfizer Investigational Site
Jacksonville, Florida 32216
2458
mi
from 98109
Jacksonville, FL
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Pfizer Investigational Site
La Jolla, California 92037
1056
mi
from 98109
La Jolla, CA
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Pfizer Investigational Site
Las Vegas, Nevada 89128
868
mi
from 98109
Las Vegas, NV
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Pfizer Investigational Site
Lexington, Kentucky 40504
2003
mi
from 98109
Lexington, KY
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Pfizer Investigational Site
Los Angeles, California 90027
979
mi
from 98109
Los Angeles, CA
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Pfizer Investigational Site
Madison, Wisconsin 53713
1618
mi
from 98109
Madison, WI
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Pfizer Investigational Site
Martinez, California 94553
?
mi
from 98109
Martinez, CA
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Pfizer Investigational Site
Miami Beach, Florida 33139
2733
mi
from 98109
Miami Beach, FL
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Pfizer Investigational Site
Nashville, Tennessee 37203
1971
mi
from 98109
Nashville, TN
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Pfizer Investigational Site
New Haven, Connecticut 06504
2432
mi
from 98109
New Haven, CT
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Pfizer Investigational Site
New York, New York 10029
2402
mi
from 98109
New York, NY
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Pfizer Investigational Site
Newport Beach, California 92663
995
mi
from 98109
Newport Beach, CA
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Pfizer Investigational Site
North Charleston, South Carolina 29406
2415
mi
from 98109
North Charleston, SC
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Pfizer Investigational Site
Orange, California 92868
984
mi
from 98109
Orange, CA
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Pfizer Investigational Site
Palo Alto, California 94304
708
mi
from 98109
Palo Alto, CA
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Pfizer Investigational Site
Philadelphia, Pennsylvania 19134
2375
mi
from 98109
Philadelphia, PA
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Pfizer Investigational Site
Pittsburgh, Pennsylvania 15212
2131
mi
from 98109
Pittsburgh, PA
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Pfizer Investigational Site
Portland, Oregon 97210
145
mi
from 98109
Portland, OR
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Pfizer Investigational Site
Providence, Rhode Island 02905
2487
mi
from 98109
Providence, RI
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Pfizer Investigational Site
Rochester, New York 14642
2154
mi
from 98109
Rochester, NY
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Pfizer Investigational Site
Sacramento, California 95816
627
mi
from 98109
Sacramento, CA
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Pfizer Investigational Site
Saint Louis, Missouri 63139
1716
mi
from 98109
Saint Louis, MO
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Pfizer Investigational Site
Salt Lake City, Utah 84103
700
mi
from 98109
Salt Lake City, UT
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Pfizer Investigational Site
San Diego, California 92123
1059
mi
from 98109
San Diego, CA
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Pfizer Investigational Site
San Francisco, California 94115
680
mi
from 98109
San Francisco, CA
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Pfizer Investigational Site
Seattle, Washington 98166
12
mi
from 98109
Seattle, WA
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Pfizer Investigational Site
Sun City, Arizona 85372
1099
mi
from 98109
Sun City, AZ
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Pfizer Investigational Site
Tampa, Florida 33609
2525
mi
from 98109
Tampa, FL
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Pfizer Investigational Site
Vista, California 92083
1031
mi
from 98109
Vista, CA
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Pfizer Investigational Site
Washington, District of Columbia 20003
2322
mi
from 98109
Washington,
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