A Phase 2 Study Evaluating The Efficacy And Safety Of PF 04494700 In Mild To Moderate Alzheimer's Disease



Status:Completed
Conditions:Alzheimer Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:50 - Any
Updated:12/2/2018
Start Date:December 2007
End Date:December 2010

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Trial Summary
Trial Overview
Inclusion Criteria

A Double Blind, Placebo Controlled, Randomized, Multicenter Study Evaluating The Efficacy And Safety Of Eighteen Months Of Treatment With PF 04494700 (TTP488) In Participants With Mild To Moderate Alzheimer's Disease

The purpose of this study is to evaluate the efficacy and safety of PF 04494700 in
participants with mild to moderate Alzheimer's disease.


Inclusion Criteria:

- Mini Mental State Exam (MMSE) score between 14-26 (inclusive) at screening.

- Participants must be receiving acetylcholinesterase inhibitors on a stable dose for at
least 4 months prior to randomization

Exclusion Criteria:

- Current evidence or history of neurological, psychiatric and any other illness that
could contribute to non-Alzheimer's dementia.

- Known history of familial AD or any evidence for early onset AD known or possibly
associated with genetic mutations.

- Evidence or history of diabetes mellitus Type 1 or Type 2.

- History or symptoms of autoimmune disorders.
We found this trial at
43
sites
Pfizer Investigational Site
Las Vegas, Nevada 89128
2372
mi
from 02139
Las Vegas, NV
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Ann Arbor, Michigan 48109
641
mi
from 02139
Ann Arbor, MI
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Pfizer Investigational Site
Atlanta, Georgia 30309
932
mi
from 02139
Atlanta, GA
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Baltimore, Maryland 21234
350
mi
from 02139
Baltimore, MD
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Beachwood, Ohio 44122
?
mi
from 02139
Beachwood, OH
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Boston, Massachusetts 02115
2
mi
from 02139
Boston, MA
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Charleston, South Carolina 29425
819
mi
from 02139
Charleston, SC
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Pfizer Investigational Site
Chicago, Illinois 60611
845
mi
from 02139
Chicago, IL
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Pfizer Investigational Site
Dallas, Texas 75204
1545
mi
from 02139
Dallas, TX
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Pfizer Investigational Site
Grand Rapids, Michigan 49506
737
mi
from 02139
Grand Rapids, MI
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Pfizer Investigational Site
Houston, Texas 77030
1606
mi
from 02139
Houston, TX
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Pfizer Investigational Site
Indianapolis, Indiana 46234
811
mi
from 02139
Indianapolis, IN
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Pfizer Investigational Site
Irvine, California 92606
2578
mi
from 02139
Irvine, CA
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Pfizer Investigational Site
Jacksonville, Florida 32216
1015
mi
from 02139
Jacksonville, FL
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La Jolla, California 92037
2578
mi
from 02139
La Jolla, CA
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Pfizer Investigational Site
Lexington, Kentucky 40504
768
mi
from 02139
Lexington, KY
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Pfizer Investigational Site
Los Angeles, California 90027
2599
mi
from 02139
Los Angeles, CA
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Madison, Wisconsin 53713
927
mi
from 02139
Madison, WI
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Martinez, California 94553
?
mi
from 02139
Martinez, CA
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Miami Beach, Florida 33139
1255
mi
from 02139
Miami Beach, FL
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Nashville, Tennessee 37203
940
mi
from 02139
Nashville, TN
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New Haven, Connecticut 06504
119
mi
from 02139
New Haven, CT
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New York, New York 10029
182
mi
from 02139
New York, NY
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Newport Beach, California 92663
2586
mi
from 02139
Newport Beach, CA
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North Charleston, South Carolina 29406
815
mi
from 02139
North Charleston, SC
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Orange, California 92868
2578
mi
from 02139
Orange, CA
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Palo Alto, California 94304
2689
mi
from 02139
Palo Alto, CA
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Philadelphia, Pennsylvania 19134
264
mi
from 02139
Philadelphia, PA
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Phoenix, Arizona 85016
2288
mi
from 02139
Phoenix, AZ
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Pittsburgh, Pennsylvania 15212
479
mi
from 02139
Pittsburgh, PA
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Portland, Oregon 97210
2532
mi
from 02139
Portland, OR
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Providence, Rhode Island 02905
42
mi
from 02139
Providence, RI
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Rochester, New York 14642
339
mi
from 02139
Rochester, NY
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Sacramento, California 95816
2620
mi
from 02139
Sacramento, CA
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Saint Louis, Missouri 63139
1038
mi
from 02139
Saint Louis, MO
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Salt Lake City, Utah 84103
2087
mi
from 02139
Salt Lake City, UT
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San Diego, California 92123
2571
mi
from 02139
San Diego, CA
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San Francisco, California 94115
2691
mi
from 02139
San Francisco, CA
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Pfizer Investigational Site
Seattle, Washington 98166
2486
mi
from 02139
Seattle, WA
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Sun City, Arizona 85372
2296
mi
from 02139
Sun City, AZ
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Tampa, Florida 33609
1184
mi
from 02139
Tampa, FL
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Pfizer Investigational Site
Vista, California 92083
2565
mi
from 02139
Vista, CA
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Pfizer Investigational Site
Washington, District of Columbia 20003
392
mi
from 02139
Washington,
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