A Phase 2 Study Evaluating The Efficacy And Safety Of PF 04494700 In Mild To Moderate Alzheimer's Disease



Status:Completed
Conditions:Alzheimer Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:50 - Any
Updated:12/2/2018
Start Date:December 2007
End Date:December 2010

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Trial Summary
Trial Overview
Inclusion Criteria

A Double Blind, Placebo Controlled, Randomized, Multicenter Study Evaluating The Efficacy And Safety Of Eighteen Months Of Treatment With PF 04494700 (TTP488) In Participants With Mild To Moderate Alzheimer's Disease

The purpose of this study is to evaluate the efficacy and safety of PF 04494700 in
participants with mild to moderate Alzheimer's disease.


Inclusion Criteria:

- Mini Mental State Exam (MMSE) score between 14-26 (inclusive) at screening.

- Participants must be receiving acetylcholinesterase inhibitors on a stable dose for at
least 4 months prior to randomization

Exclusion Criteria:

- Current evidence or history of neurological, psychiatric and any other illness that
could contribute to non-Alzheimer's dementia.

- Known history of familial AD or any evidence for early onset AD known or possibly
associated with genetic mutations.

- Evidence or history of diabetes mellitus Type 1 or Type 2.

- History or symptoms of autoimmune disorders.
We found this trial at
43
sites
Pfizer Investigational Site
La Jolla, California 92037
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Ann Arbor, Michigan 48109
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Ann Arbor, MI
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Atlanta, Georgia 30309
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Atlanta, GA
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Baltimore, Maryland 21234
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Baltimore, MD
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Beachwood, Ohio 44122
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Beachwood, OH
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Boston, Massachusetts 02115
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Boston, MA
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Charleston, South Carolina 29425
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Charleston, SC
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Chicago, Illinois 60611
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Chicago, IL
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Dallas, Texas 75204
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Dallas, TX
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Grand Rapids, Michigan 49506
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Grand Rapids, MI
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Houston, Texas 77030
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Houston, TX
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Indianapolis, Indiana 46234
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Indianapolis, IN
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Irvine, California 92606
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Irvine, CA
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Jacksonville, Florida 32216
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Jacksonville, FL
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Las Vegas, Nevada 89128
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Las Vegas, NV
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Lexington, Kentucky 40504
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Lexington, KY
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Los Angeles, California 90027
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Los Angeles, CA
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Madison, Wisconsin 53713
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Martinez, California 94553
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Martinez, CA
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Miami Beach, Florida 33139
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Miami Beach, FL
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Nashville, Tennessee 37203
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New Haven, Connecticut 06504
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New Haven, CT
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New York, New York 10029
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Newport Beach, California 92663
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North Charleston, South Carolina 29406
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Orange, California 92868
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Orange, CA
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Palo Alto, California 94304
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Philadelphia, Pennsylvania 19134
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Philadelphia, PA
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Phoenix, Arizona 85016
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Pittsburgh, Pennsylvania 15212
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Portland, Oregon 97210
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Portland, OR
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Providence, Rhode Island 02905
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Providence, RI
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Rochester, New York 14642
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Rochester, NY
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Sacramento, California 95816
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Sacramento, CA
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Saint Louis, Missouri 63139
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Salt Lake City, Utah 84103
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San Diego, California 92123
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San Francisco, California 94115
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Seattle, Washington 98166
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Seattle, WA
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Sun City, Arizona 85372
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Tampa, Florida 33609
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Tampa, FL
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Vista, California 92083
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Washington, District of Columbia 20003
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