A Phase 2 Study Evaluating The Efficacy And Safety Of PF 04494700 In Mild To Moderate Alzheimer's Disease



Status:Completed
Conditions:Alzheimer Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:50 - Any
Updated:12/2/2018
Start Date:December 2007
End Date:December 2010

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Trial Summary
Trial Overview
Inclusion Criteria

A Double Blind, Placebo Controlled, Randomized, Multicenter Study Evaluating The Efficacy And Safety Of Eighteen Months Of Treatment With PF 04494700 (TTP488) In Participants With Mild To Moderate Alzheimer's Disease

The purpose of this study is to evaluate the efficacy and safety of PF 04494700 in
participants with mild to moderate Alzheimer's disease.


Inclusion Criteria:

- Mini Mental State Exam (MMSE) score between 14-26 (inclusive) at screening.

- Participants must be receiving acetylcholinesterase inhibitors on a stable dose for at
least 4 months prior to randomization

Exclusion Criteria:

- Current evidence or history of neurological, psychiatric and any other illness that
could contribute to non-Alzheimer's dementia.

- Known history of familial AD or any evidence for early onset AD known or possibly
associated with genetic mutations.

- Evidence or history of diabetes mellitus Type 1 or Type 2.

- History or symptoms of autoimmune disorders.
We found this trial at
43
sites
Pfizer Investigational Site
Ann Arbor, Michigan 48109
165
mi
from 43215
Ann Arbor, MI
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Pfizer Investigational Site
Atlanta, Georgia 30309
432
mi
from 43215
Atlanta, GA
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Pfizer Investigational Site
Baltimore, Maryland 21234
346
mi
from 43215
Baltimore, MD
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Pfizer Investigational Site
Beachwood, Ohio 44122
?
mi
from 43215
Beachwood, OH
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Pfizer Investigational Site
Boston, Massachusetts 02115
643
mi
from 43215
Boston, MA
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Pfizer Investigational Site
Charleston, South Carolina 29425
524
mi
from 43215
Charleston, SC
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Pfizer Investigational Site
Chicago, Illinois 60611
274
mi
from 43215
Chicago, IL
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Pfizer Investigational Site
Dallas, Texas 75204
910
mi
from 43215
Dallas, TX
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Pfizer Investigational Site
Grand Rapids, Michigan 49506
245
mi
from 43215
Grand Rapids, MI
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Pfizer Investigational Site
Houston, Texas 77030
995
mi
from 43215
Houston, TX
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Pfizer Investigational Site
Indianapolis, Indiana 46234
175
mi
from 43215
Indianapolis, IN
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Pfizer Investigational Site
Irvine, California 92606
1959
mi
from 43215
Irvine, CA
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Pfizer Investigational Site
Jacksonville, Florida 32216
673
mi
from 43215
Jacksonville, FL
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Pfizer Investigational Site
La Jolla, California 92037
1954
mi
from 43215
La Jolla, CA
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Pfizer Investigational Site
Las Vegas, Nevada 89128
1762
mi
from 43215
Las Vegas, NV
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Pfizer Investigational Site
Lexington, Kentucky 40504
156
mi
from 43215
Lexington, KY
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Los Angeles, California 90027
1982
mi
from 43215
Los Angeles, CA
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Madison, Wisconsin 53713
391
mi
from 43215
Madison, WI
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Martinez, California 94553
?
mi
from 43215
Martinez, CA
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Pfizer Investigational Site
Miami Beach, Florida 33139
993
mi
from 43215
Miami Beach, FL
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Nashville, Tennessee 37203
333
mi
from 43215
Nashville, TN
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Pfizer Investigational Site
New Haven, Connecticut 06504
536
mi
from 43215
New Haven, CT
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Pfizer Investigational Site
New York, New York 10029
481
mi
from 43215
New York, NY
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Newport Beach, California 92663
1967
mi
from 43215
Newport Beach, CA
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North Charleston, South Carolina 29406
516
mi
from 43215
North Charleston, SC
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Orange, California 92868
1959
mi
from 43215
Orange, CA
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Palo Alto, California 94304
2102
mi
from 43215
Palo Alto, CA
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Philadelphia, Pennsylvania 19134
419
mi
from 43215
Philadelphia, PA
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Phoenix, Arizona 85016
1658
mi
from 43215
Phoenix, AZ
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Pittsburgh, Pennsylvania 15212
162
mi
from 43215
Pittsburgh, PA
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Portland, Oregon 97210
2029
mi
from 43215
Portland, OR
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Providence, Rhode Island 02905
619
mi
from 43215
Providence, RI
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Pfizer Investigational Site
Rochester, New York 14642
358
mi
from 43215
Rochester, NY
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Sacramento, California 95816
2042
mi
from 43215
Sacramento, CA
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Pfizer Investigational Site
Saint Louis, Missouri 63139
399
mi
from 43215
Saint Louis, MO
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Salt Lake City, Utah 84103
1510
mi
from 43215
Salt Lake City, UT
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San Diego, California 92123
1947
mi
from 43215
San Diego, CA
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San Francisco, California 94115
2108
mi
from 43215
San Francisco, CA
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Pfizer Investigational Site
Seattle, Washington 98166
2007
mi
from 43215
Seattle, WA
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Sun City, Arizona 85372
1667
mi
from 43215
Sun City, AZ
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Tampa, Florida 33609
831
mi
from 43215
Tampa, FL
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Pfizer Investigational Site
Vista, California 92083
1942
mi
from 43215
Vista, CA
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Pfizer Investigational Site
Washington, District of Columbia 20003
328
mi
from 43215
Washington,
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