Burn Healing and Analgesia With Propranolol

Inclusion Criteria:

- Thermal burn

- Greater than or equal to 18 years of age

- Less than 60 years of age

- Able to speak and read English

Exclusion Criteria:

- Intubated

- Clinically unstable

- Other substantial comorbid injury (e.g. long bone fracture)

- Heart block greater than first degree (EKG)

- History of coronary artery disease

- History of congestive heart failure

- Asthma (within past 10 years, induced by a beta-blocker, or receiving current
treatment)

- Pregnant

- Prisoner

- Psychotic, suicidal, or homicidal

- Diabetic

- Hepatic failure (acute or chronic)

- Renal failure (acute or chronic)

- History of hyperthyroidism unless taking synthroid or other thyroid hormone
replacement

- Exceeds daily acceptable chronic opioid use prior to burn

- Interacting medication

- Received propranolol within the last 6 months

- Multiple severe allergic reactions

- On daily methylphenidate or similar stimulant medication

- Unwilling to use medically acceptable birth control (if childbearing potential)

- Breastfeeding

- Severe peripheral vascular disease or vasospastic disorder

- Bradycardia that in the opinion of the investigator would constitute too great a risk
when considered in the context of the patient's medical comorbidities and health
history

- Other criteria that in investigator's opinion makes participant poor candidate for the
trial

- Cancer (except basal cell cancer)