Human Immunome Program
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 49 |
| Updated: | 1/11/2019 |
| Start Date: | July 1, 2017 |
| End Date: | April 30, 2028 |
The Human Immunome Program is a large-scale, open-source effort seeking to fill a major gap
in our knowledge of the immune system. The power of the immune system to fight disease lies
in its ability recognize and adapt to an astonishing range of threats from viruses, parasites
and bacteria to cancer cells. Underlying this ability is a vast but specific set of genes and
molecular structures known as the human immunome, or the "parts list" of the immune system.
This study aims to decipher the genetic sequences that make up this part list and link it to
information about a person's microbiome composition and characteristics such as health
history, race, and demographics over time. This information, made freely available to the
public for use in research in de-identified form, will allow investigators to answer a wide
variety of different questions about immune system function. This could transform how we
diagnose, prevent and treat disease though the identification of new biomarkers while
enabling highly targeted, computationally designed vaccines and therapies that reduce time
and risk of product development.
in our knowledge of the immune system. The power of the immune system to fight disease lies
in its ability recognize and adapt to an astonishing range of threats from viruses, parasites
and bacteria to cancer cells. Underlying this ability is a vast but specific set of genes and
molecular structures known as the human immunome, or the "parts list" of the immune system.
This study aims to decipher the genetic sequences that make up this part list and link it to
information about a person's microbiome composition and characteristics such as health
history, race, and demographics over time. This information, made freely available to the
public for use in research in de-identified form, will allow investigators to answer a wide
variety of different questions about immune system function. This could transform how we
diagnose, prevent and treat disease though the identification of new biomarkers while
enabling highly targeted, computationally designed vaccines and therapies that reduce time
and risk of product development.
Inclusion Criteria:
- Healthy male and female volunteers between the ages of 18 - 49 years of age at the
time of first enrollment.
- Ability to comply: Participant willing and able to comply with the requirements of the
protocol.
- Consent: Participants who have given informed consent for participation in the study
Exclusion Criteria:
Reason for exclusion throughout the entire study period:
- History of severe anemia requiring blood transfusion or current Hemoglobin < 10g/dL.
- Currently pregnant or pregnancy within 6 months.
- Current participation in another study resulting in blood collection which exceeds 550
ml in an 8 week period or occurs more frequently than 2 times per week.
- Temperature >101.4F
- Any condition which, in the opinion of the investigator, might interfere with study
objectives.
- Any reason which, in the opinion of the investigator, adds additional risk to the
patient.
Reason for exclusion in year 0 but not in year 1-9:
- History of known HIV infection or treatment.
- Immunosuppressive disease or use of systemic immunosuppressive therapy using drugs or
cytotoxic agents including prednisone (IV, oral or inhaled) less than 6 months ago.
- History of diabetes mellitus -or a glucose (on CMP) ≥200 mg/dL.
- History of cancer including skin cancer.
- History of autoimmune disorders including but not limited to: Ulcerative colitis,
Crohn's, Inflammatory Bowel Disease, Rheumatoid Arthritis, Scleroderma, Systemic lupus
Erythematosus, Mixed Connective Tissue Disease, Graves, Autoimmune Thyroiditis,
Hashimoto's Thyroiditis, Psoriasis, Multiple Sclerosis, Guillain-Barre Syndrome,
Chronic Inflammatory demyelinating polyneuropathy, Myasthenia Gravis, Vasculitis,
Alopecia areata, autoimmune hemolytic anemia, autoimmune hepatitis, dermatomyositis,
idiopathic thrombocytopenic purpura, pemphigus, pernicious anemia, polyarteritis
nodosa, polymyositis, Sjogren's Syndrome, Wegener's
- Severe obesity = (BMI >40 kg/m2).
We found this trial at
1
site
1211 Medical Center Dr
Nashville, Tennessee 37232
Nashville, Tennessee 37232
(615) 322-5000
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
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