Correlation of Ultrasound Based Measurements of Liver Stiffness and Steatosis With MRI

Non-invasive monitoring of liver fibrosis using magnetic resonance imaging (MRI) can help
determine which patients will most benefit from interventional therapies to help reverse the
condition. Similarly, quantitative assessment of liver fat content using MRI can assist
physicians in identifying patients at risk for hepatic steatohepatitis.

Due to the widespread dissemination of US machines and their relative lower cost compared to
other imaging modalities, e.g. MRI, the ability of US to assess these parameters widens
diagnostic availability.

Patients who have undergone an MRI exam to assess liver stiffness (cirrhosis) and/or liver
fat content (steatosis) will be asked to undergo an US exam to assess the same parameters.
The cirrhosis and steatosis measurements obtained from both exams will be compared. If
US-based measurements of liver stiffness and/or liver fat content are shown to be
reproducible and accurate when compared to MRI values (will be used as the gold standard), US
may become the first-line diagnostic test for these liver conditions.

Inclusion Criteria:

1. participants who have a clinical indication for a standard of care MRI exam that
included assessment of the liver

2. participant is at least 18 years of age

Exclusion Criteria:

1. Participants unable to take part in the decision making process on whether to consent
to the trial

2. Patients with previous chemoembolization or other focal liver therapies to the liver
(* NOTE: for liver transplant patients, this criterion is only applicable to the
transplanted liver)