A Dose Ranging Study of OPT-302 With Ranibizumab in Neovascular (Wet) AMD



Status:Active, not recruiting
Conditions:Ocular
Therapuetic Areas:Ophthalmology
Healthy:No
Age Range:50 - Any
Updated:11/30/2018
Start Date:November 6, 2017
End Date:March 2020

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A Dose-Ranging Study of Intravitreal OPT-302 in Combination With Ranibizumab, Compared With Ranibizumab Alone, in Participants With Neovascular Age-Related Macular Degeneration (Wet AMD)

A multicentre, randomised, parallel group, sham-controlled, double-masked, dose-ranging
study, investigating two doses of OPT-302 in combination with ranibizumab compared with
ranibizumab with sham, over six consecutive monthly dosing cycles in participants with
neovascular (wet) AMD.


Inclusion Criteria:

- Active subfoveal choroidal neovascular (CNV) lesion or juxtafoveal lesion secondary to
age-related macular AMD

- An ETDRS BCVA score between 60 and 25 (inclusive) letters

Exclusion Criteria:

- Previous treatment for wet AMD or previous treatment for CNV due to other causes in
the Study Eye

- Clinically significant ocular disorders which may interfere with assessment of visual
acuity, assessment of toxicity, or fundus photography in the Study Eye

- Poorly controlled diabetes mellitus (defined as HbA1c>7%)

- Any clinically significant cardiovascular, renal or hepatic conditions, recent
surgery, or malignancy, that would make the participant unsuitable for the study
We found this trial at
51
sites
Paducah, Kentucky 42001
361
mi
from 43215
Paducah, KY
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Abilene, Texas 79606
1063
mi
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Abilene, TX
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Albuquerque, New Mexico 87109
1327
mi
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Albuquerque, NM
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Asheville, North Carolina 28803
304
mi
from 43215
Asheville, NC
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Augusta, Georgia 30909
452
mi
from 43215
Augusta, GA
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Austin, Texas 78705
1064
mi
from 43215
Austin, TX
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Baltimore, Maryland 21204
341
mi
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Baltimore, MD
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Beverly Hills, California 90211
1979
mi
from 43215
Beverly Hills, CA
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Boynton Beach, Florida 33426
943
mi
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Boynton Beach, FL
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Camp Hill, Pennsylvania 17011
323
mi
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Camp Hill, PA
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Charlotte, North Carolina 28210
354
mi
from 43215
Charlotte, NC
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Cleveland, Ohio 44122
131
mi
from 43215
Cleveland, OH
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Colorado Springs, Colorado 80909
1161
mi
from 43215
Colorado Springs, CO
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Columbus, Ohio 43212
1
mi
from 43215
Columbus, OH
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Edison, New Jersey 08820
458
mi
from 43215
Edison, NJ
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Encino, California 91436
1984
mi
from 43215
Encino, CA
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Fairfax, Virginia 22031
314
mi
from 43215
Fairfax, VA
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Fort Myers, Florida 33912
924
mi
from 43215
Fort Myers, FL
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Golden, Colorado 80401
1174
mi
from 43215
Golden, CO
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Grand Rapids, Michigan 49546
241
mi
from 43215
Grand Rapids, MI
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Houston, Texas 77030
995
mi
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Houston, TX
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Hradec Králové, 50005
?
mi
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Hradec Králové,
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Kingston, Pennsylvania 18704
384
mi
from 43215
Kingston, PA
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Las Vegas, Nevada 89144
1765
mi
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Las Vegas, NV
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Lynbrook, New York 11563
494
mi
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Lynbrook, NY
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Melbourne, Florida 32901
833
mi
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Melbourne, FL
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Palm Desert, California 92260
?
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Palm Desert, CA
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Pensacola, Florida 32503
697
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Pensacola, FL
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Philadelphia, Pennsylvania 19107
?
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Philadelphia, PA
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Phoenix, Arizona 85014
1660
mi
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Phoenix, AZ
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Portland, Oregon 97239
2026
mi
from 43215
Portland, OR
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Redlands, California 92374
1914
mi
from 43215
Redlands, CA
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Reno, Nevada 89502
1936
mi
from 43215
Reno, NV
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Rochester, New York 14620
355
mi
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Rochester, NY
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Sacramento, California 95819
2041
mi
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Sacramento, CA
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Saint Petersburg, Florida 33703
839
mi
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Saint Petersburg, FL
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San Antonio, Texas 78240
1138
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San Antonio, TX
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San Diego, California 94143
?
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San Diego, CA
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Santa Ana, California 92705
2020
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Santa Ana, CA
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Santa Barbara, California 93103
2039
mi
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Santa Barbara, CA
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Santa Maria, California 93454
2065
mi
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Santa Maria, CA
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Shawnee Mission, Kansas 66204
624
mi
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Shawnee Mission, KS
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Silverdale, Washington 98383
2023
mi
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Silverdale, WA
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Tallahassee, Florida 32308
662
mi
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Tallahassee, FL
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Teaneck, New Jersey 07666
478
mi
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Teaneck, NJ
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The Woodlands, Texas 77384
971
mi
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The Woodlands, TX
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Virginia Beach, Virginia 23462
430
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Virginia Beach, VA
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West Columbia, South Carolina 29169
426
mi
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West Columbia, SC
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Wichita, Kansas 67214
783
mi
from 43215
Wichita, KS
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Willow Park, Texas 76087
999
mi
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Willow Park, TX
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Winter Haven, Florida 33800
828
mi
from 43215
Winter Haven, FL
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