HRIM vs Mucosal Impedance in GERD Participants
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Gastroesophageal Reflux Disease |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 8/17/2018 |
| Start Date: | June 2016 |
| End Date: | September 2019 |
Baseline Impedance Measured on High Resolution Esophageal Impedance Manometry to Discriminate GERD From Non GERD Patients
Does baseline impedance measured during the landmark phase of esophageal High resolution
impedance manometry HRIM correlates with direct mucosal impedance measurement and
discriminates GERD from non GERD patients?
impedance manometry HRIM correlates with direct mucosal impedance measurement and
discriminates GERD from non GERD patients?
Patients referred to the Mayo Clinic Rochester for a clinically indicated high resolution
impedance manometry (HRIM), 24 hour impedance pH (MII-pH) study, and
esophagogastroduodenoscopy (EGD) will be recruited. Gastroesophageal reflux will be defined
as a total 24 hour esophageal acid exposure time ≥5% regardless of concomitant Proton Pump
inhibitor (PPI) use. A negative 24 hour MII-pH study will be defined as an acid exposure time
≤2% off PPI therapy or ≤1% if on PPI therapy.
impedance manometry (HRIM), 24 hour impedance pH (MII-pH) study, and
esophagogastroduodenoscopy (EGD) will be recruited. Gastroesophageal reflux will be defined
as a total 24 hour esophageal acid exposure time ≥5% regardless of concomitant Proton Pump
inhibitor (PPI) use. A negative 24 hour MII-pH study will be defined as an acid exposure time
≤2% off PPI therapy or ≤1% if on PPI therapy.
Patients being seen at Mayo clinic Rochester having a clinically indicated endoscopy, a
high resolution impedance manometry and a 24 hour pH impedance study.
Inclusion criteria:
- Adults ages 18-90
- Patients scheduled for or have completed a HRIM ( within 5 days)
- Patients scheduled for or recently have completed a MII-pH studies ( within 5 days)
- Patients scheduled for EGD
Exclusion criteria:
- Technically limited esophageal HRIM or MII-pH study
- Patients with HRIM and MII-pH studies not performed within 5 days of each other
- Patients with EGD not performed within 30 days of HRIM and MII-pH studies
- Medical conditions such as severe heart or lung disease that preclude safe performance
of endoscopy
- Inability to read due to: Blindness, cognitive dysfunction, or English language
illiteracy
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