Delineating Swallowing Impairment and Decline in ALS
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology, Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 11/21/2018 |
| Start Date: | May 31, 2017 |
| End Date: | June 30, 2024 |
| Contact: | Raele Robison, MS |
| Email: | raerobison1@ufl.edu |
| Phone: | 6105044605 |
Delineating Physiologic Mechanisms of Swallowing Impairment and Decline in ALS
Individuals with Amyotrophic Lateral Sclerosis are at high risk for swallowing impairment
(dysphagia) which leads to malnutrition, decreased pulmonary health, aspiration and
aspiration pneumonia. These sequelae necessitate timely identification of at risk individuals
to ensure optimal management of oral intake and pulmonary function. The purpose of this study
is to evaluate the discriminant ability of several non-invasive screening tools at detecting
swallowing impairment in individuals with ALS.
(dysphagia) which leads to malnutrition, decreased pulmonary health, aspiration and
aspiration pneumonia. These sequelae necessitate timely identification of at risk individuals
to ensure optimal management of oral intake and pulmonary function. The purpose of this study
is to evaluate the discriminant ability of several non-invasive screening tools at detecting
swallowing impairment in individuals with ALS.
This research study is being performed to determine screening tools or tests that are able to
identify and track swallowing problems associated with Amyotrophic Lateral Sclerosis (ALS)
over time. Also, this study will provide insight into the natural progression of swallowing
impairment in persons with ALS over time.
Participants enrolled in this study will complete one evaluation at the University of Florida
Swallowing Systems Core laboratory located at Shands Hospital, Gainesville every three
months. Each evaluation will take approximately 90 minutes. During these evaluations, a
videofluoroscopy (X-ray of swallowing) examination, cough tests and questionnaires will be
completed.
identify and track swallowing problems associated with Amyotrophic Lateral Sclerosis (ALS)
over time. Also, this study will provide insight into the natural progression of swallowing
impairment in persons with ALS over time.
Participants enrolled in this study will complete one evaluation at the University of Florida
Swallowing Systems Core laboratory located at Shands Hospital, Gainesville every three
months. Each evaluation will take approximately 90 minutes. During these evaluations, a
videofluoroscopy (X-ray of swallowing) examination, cough tests and questionnaires will be
completed.
Inclusion Criteria:
- diagnosis of probable or definite ALS
- diagnosis within 120 days
Exclusion Criteria:
- allergies to barium or capsaicin
- History of stroke
- Head and Neck Cancer
- Other disorder that might contribute to swallowing impairment
- Not enrolled in other research investigations that might impact swallowing
- Not pregnant
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