dbGaP Protocol: The Pediatric Cardiac Genetics Consortium (PCGC)
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | Any - 60 |
| Updated: | 4/6/2019 |
| Start Date: | April 10, 2019 |
| End Date: | October 31, 2021 |
Background:
Researchers do not know much about the causes of congenital heart disease (CHD). They do know
that many factors play a role. Some factors are environmental. Some are genetic. But few
specific factors have been identified. And researchers do not know how many involve genes.
They want to study data that has already been collected from people with CHD and their
families.
Objectives:
To identify genetic variations related to CHD. To study molecules related to vascular disease
in order to learn new ways to treat it.
Eligibility:
People who already participated in the Pediatric Cardiac Genomics Consortium (PCGC) study
Design:
Researchers will study data that was already collected in the PCGC. There will be no active
participants.
Researchers will get access to the data through the coordinating center. They will not
download data to local storage devices.
The data will have no personally identifying information....
Researchers do not know much about the causes of congenital heart disease (CHD). They do know
that many factors play a role. Some factors are environmental. Some are genetic. But few
specific factors have been identified. And researchers do not know how many involve genes.
They want to study data that has already been collected from people with CHD and their
families.
Objectives:
To identify genetic variations related to CHD. To study molecules related to vascular disease
in order to learn new ways to treat it.
Eligibility:
People who already participated in the Pediatric Cardiac Genomics Consortium (PCGC) study
Design:
Researchers will study data that was already collected in the PCGC. There will be no active
participants.
Researchers will get access to the data through the coordinating center. They will not
download data to local storage devices.
The data will have no personally identifying information....
Current understanding of the causes of congenital heart disease (CHD) is limited, but CHD is
known to be multifactorial and affected by a combination of environmental, teratogenic, and
genetic causes. Furthermore, both genetic and environmental factors have been proposed to act
as disease modifiers, accounting for a wide variation in phenotypic expression and clinical
outcomes of these disorders. To date however, few specific genetic or environmental causative
factors have been identified, nor is it even known what proportion of cases involve genetic
factors.
known to be multifactorial and affected by a combination of environmental, teratogenic, and
genetic causes. Furthermore, both genetic and environmental factors have been proposed to act
as disease modifiers, accounting for a wide variation in phenotypic expression and clinical
outcomes of these disorders. To date however, few specific genetic or environmental causative
factors have been identified, nor is it even known what proportion of cases involve genetic
factors.
- Retrospective Analysis Study. Data will be analyzed from subjects from cardiovascular
disease databases.
We found this trial at
1
site
Click here to add this to my saved trials
