Verapamil for Neuroprotection in Stroke



Status:Recruiting
Conditions:Peripheral Vascular Disease, Neurology
Therapuetic Areas:Cardiology / Vascular Diseases, Neurology
Healthy:No
Age Range:18 - 80
Updated:11/22/2017
Start Date:April 20, 2017
End Date:April 2020

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Trial Summary
Trial Overview
Inclusion Criteria

Intraarterial Verapamil for Neuroprotection in Ischemic Stroke

The purpose of this research study is to test an experimental procedure called intra-arterial
delivery of verapamil in patients diagnosed with acute ischemic stroke. This study
investigates the safety of intra-arterial delivery of verapamil, a drug used to treat
vasospasm (spasm of a blood vessel), and how it affects recovery from stroke. Recruitment is
limited to patients that have received mechanical thrombectomy as standard of care.


Inclusion Criteria:

- Written informed consent

- 18 years of age and over

- Acute onset focal neurologic deficit consistent with acute ischemic stroke, or
computed tomographic scan consistent with acute cerebral ischemia

- Candidate for mechanical thrombectomy procedure

- Onset of symptoms less than 8 hours

- Measurable neurologic deficit (NIHSS >1)

- Willingness to follow up with rehabilitation therapy

- Anticipated life expectancy of at least 3 months

Exclusion Criteria:

- Pregnancy or suspected pregnancy (pregnancy test will be done on women of
child-bearing potential)

- Hepatic and/or renal insufficiency (LFT's>3× upper limit of normal; CrCl < 30ml/min)

- Thrombocytopenia (platelet count <75,000/mm3)

- History of intolerance to verapamil

- Previous functional disability (modified Rankin > 1)

- Stuporous or comatose

- Unlikely to be available for 90 day follow-up

- Severe stroke (NIHSS>22)
We found this trial at
1
site
Our Lady of Lourdes Medical Center
Camden, New Jersey 08103
Phone: 888-568-7337
?
mi
from
Camden, NJ
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