[11C]NOP-1A and Cocaine Use Disorders

This will allow for understanding brain stress and anti-stress mechanisms that underlie abuse
of cocaine in humans.

[A]Cocaine use disorders

Inclusion criteria:

1. Males or Females 18-50

2. Fulfill DSM-5 Diagnosis for Cocaine use disorder

3. Medically Healthy

Major exclusion criteria:

1. Pregnancy or lactation

2. Comorbid medical, psychiatric, drug use disorders (other than cocaine, tobacco use,
and recreational marijuana/alcohol use)

3. Metal implants or paramagnetic objects contained within the body which may interfere
with the MRI scan

4. Currently employed as radiation worker; or participation in radioactive drug research
protocols within the previous year

5. Currently on any psychotropic medications that can influence nociceptin transmission
in the brain (e.g., morphine, suboxone, SSRIs, etc.)

[B] Healthy controls

Inclusion criteria:

1. Males or Females 18-50

2. Absence of present or past psychiatric conditions (including alcohol or drug use
disorders)

3. A negative urine drug screen

4. Medically Healthy

Major exclusion criteria

1. Pregnancy or lactation

2. Medical, psychiatric or drug & alcohol use disorders

3. Metal implants or paramagnetic objects contained within the body which may interfere
with the MRI scan

4. Currently employed as radiation worker; or participation in radioactive drug research
protocols within the previous year

5. Currently on any psychotropic medications that can influence nociceptin transmission
in the brain

6. Family history of a psychotic disorder, manic episode, drug use disorders in
first-degree relatives.