The Effect of Salmeterol on Eosinophil (EOS) Function
| Status: | Completed |
|---|---|
| Conditions: | Allergy, Asthma |
| Therapuetic Areas: | Otolaryngology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 11/23/2017 |
| Start Date: | November 2003 |
| End Date: | January 2008 |
This study is designed to test the hypothesis that salmeterol use, and not fluticasone use or
the combination treatment with fluticasone and salmeterol, is associated with a greater
number of sputum eosinophils following antigen challenge and, under these circumstances, the
migrating peripheral blood eosinophils are less adherent.
the combination treatment with fluticasone and salmeterol, is associated with a greater
number of sputum eosinophils following antigen challenge and, under these circumstances, the
migrating peripheral blood eosinophils are less adherent.
An antigen challenge is when a participant inhales either cat, ragweed, or dust dander in
increasing concentrations until their lung function drops 15 or 20 percent.
increasing concentrations until their lung function drops 15 or 20 percent.
Inclusion Criteria:
- 18-55 years of age
- history of asthma symptoms for the previous 6 months
- Forced Expiratory Value (FEV1) >75% of predicted
- positive prick skin test to cat, house dust mite or ragweed
Exclusion Criteria:
- history of life threatening asthma or anaphylaxis
- current smoker
- pregnant or breast-feeding
- evidence of an upper respiratory infection within 4 weeks of screening
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