A Study to Evaluate the Effect of ASP1941 in Adult Patients With Type 2 Diabetes Mellitus

Inclusion Criteria:

- Subject has been diagnosed with type 2 diabetes

- Subject has a HbA1c value between 6.8 and 9.5%

- Subject has never, is not currently taking anti-diabetic medication OR is receiving a
single anti- diabetic agent or low-doses two anti-diabetic medications and is willing
to discontinue them during the study

- Subject is on a stable diet and exercise program

- Female subject is not pregnant and agrees to use an acceptable form of contraception
throughout the duration of the study

Exclusion Criteria:

- Subject has type 1 diabetes mellitus

- Subject is using insulin therapy

- Subject has a serum creatinine higher than upper limit of normal

- Subject has an ALT and/or AST value higher than 3 times upper limit of normal or a
total bilirubin value more than 2 times upper limit of normal

- Subject has persistent, uncontrolled severe hypertension as indicated by a

systolic blood pressure >180 mmHg or a diastolic blood pressure of

>110mmHg

- Subject has had significant cardiovascular disease such as myocardial infarction or a
vascular intervention (e.g., angioplasty or stent) in the last 3 months

- Subject is known to have hepatitis or be a carrier of hepatitis B surface

antigen, hepatitis C virus antibody or is known positive for HIV1 and/or

HIV2

- Subject has a history of lactic acidosis

- Subject has a history of drug and alcohol abuse/dependency within last 12

months

- Subject has had a malignancy in the last 5 years, except for successfully

treated basal or squamous cell carcinoma of the skin or of the cervix

- Subject has a symptomatic urinary tract infection or genital infection

- Female subject is lactating

- Subject has an unstable medical or psychiatric illness