PF-06804103 Dose Escalation in HER2 Positive Solid Tumors
Status: | Recruiting |
---|---|
Conditions: | Breast Cancer, Lung Cancer, Cancer |
Therapuetic Areas: | Oncology |
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 2/7/2019 |
Start Date: | November 1, 2017 |
End Date: | June 22, 2021 |
Contact: | Pfizer CT.gov Call Center |
Email: | ClinicalTrials.gov_Inquiries@pfizer.com |
Phone: | 1-800-718-1021 |
A PHASE 1 DOSE ESCALATION STUDY EVALUATING THE SAFETY AND TOLERABILITY OF PF-06804103 IN PATIENTS WITH HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 (HER2) POSITIVE SOLID TUMORS
The study will evaluate the safety, pharmacokinetics and pharmacodynamics of increasing doses
of PF-06804103 in patients with HER2 positive solid tumors. The study will expand to look at
the selected dose in patients with breast cancer, gastric cancer and non-small cell lung
cancer
of PF-06804103 in patients with HER2 positive solid tumors. The study will expand to look at
the selected dose in patients with breast cancer, gastric cancer and non-small cell lung
cancer
Inclusion Criteria:
- HER2 positive breast cancer or gastric cancer that is resistant to standard therapy or
for which no standard therapy is available
- Performance status of 0 or 1
- Adequate bone marrow, kidney and liver function
Exclusion Criteria:
- Known CNS disease including, but not limited to, metastases
- History of exposure to certain cumulative doses of anthracyclines
- Grade 3 or higher hypersensitivity reaction to prior receipt of any antibody therapy
- Active and clinically significant bacterial, fungal, or viral infection
- Abnormal cardiac function defined by a LVEF <50% by ECHO or MUGA
- Patients with previous history or active interstitial lung disease or pulmonary
fibrosis, or a history of other clinically significant lung diseases
We found this trial at
14
sites
Los Angeles, California 90095
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Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
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1515 Holcombe Blvd
Houston, Texas 77030
Houston, Texas 77030
713-792-2121
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
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Los Angeles, California 90048
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2020 Santa Monica Boulevard
Santa Monica, California 90404
Santa Monica, California 90404
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