PF-06804103 Dose Escalation in HER2 Positive Solid Tumors

Inclusion Criteria:

- HER2 positive breast cancer or gastric cancer that is resistant to standard therapy or
for which no standard therapy is available

- Performance status of 0 or 1

- Adequate bone marrow, kidney and liver function

Exclusion Criteria:

- Known CNS disease including, but not limited to, metastases

- History of exposure to certain cumulative doses of anthracyclines

- Grade 3 or higher hypersensitivity reaction to prior receipt of any antibody therapy

- Active and clinically significant bacterial, fungal, or viral infection

- Abnormal cardiac function defined by a LVEF <50% by ECHO or MUGA

- Patients with previous history or active interstitial lung disease or pulmonary
fibrosis, or a history of other clinically significant lung diseases