Cocaine Use Disorder and Cortical Dopamine

This study seeks to examine dopamine (DA) transmission in vivo, using positron emission
tomography (PET) with [C-11]FLB 457, in cortical regions of interest in subjects who have a
history of cocaine dependence. We hypothesize that cocaine dependence is associated with
decreases in dopamine in the prefrontal cortical regions compared to controls. This may
explain the impulsivity and cognitive deficits that underlie relapse in this disorder.

Subjects with Cocaine Dependence INCLUSION CRITERIA

1. Males or Females 18-40

2. Fulfill Diagnostic and Statistical Manual (DSM-IV) Diagnosis for Cocaine Dependence

3. Medically Healthy MAJOR EXCLUSIONS

1. Major medical, psychiatric, co-morbid drug & alcohol use disorders 2. Pregnancy or
lactation, 3. Contraindications to MRI 4. Currently employed as radiation worker; or
participation in radioactive drug research protocols within the previous year 5. Family
History of a psychotic illness or manic episode in first-degree relatives

Healthy Subjects INCLUSION CRITERIA

1. Males or Females 18-40

2. Absence of present or past psychiatric conditions (including alcohol or drug
dependence)

3. A negative urine drug screen

4. Medically Healthy

MAJOR EXCLUSIONS

1. Any medical, psychiatric, co-morbid drug & alcohol use disorders

2. Pregnancy or lactation,

3. Contraindications to MRI

4. Currently employed as radiation worker; or participation in radioactive drug research
protocols within the previous year

5. Family History of a psychotic illness or manic episode, or drug and alcohol
Abuse/Dependence in first-degree relatives