Metastatic Tumor Research and Outcomes Network

To prospectively determine the prognostic variables (clinical, diagnostic, and therapeutic)
within patients diagnosed with metastatic spine tumor(s) that are associated with:

- patient reported outcomes (HRQOL)

- morbidity data

- local tumor control

- survival

Outcome measures:

Variables which will be collected in the registry that are applicable to patients with
metastatic spine tumor include:

- • Patient details

- Details of previous treatment

- Diagnosis

- Symptoms

- Treatment details for the index target

- Imaging information

The following outcome measures will be collected:

- Patient reported outcomes:

- Euroqol EQ-5D-3L

- Euroqol EQ-5D VAS - Quality of Life

- Neck Pain Numeric Rating Scale (NRS)

- Arm Pain NRS

- Back Pain NRS

- Leg Pain NRS

- SOSGOQ

- Patient assessment

- Ambulation

- Pain medication

- Nutritional Status Tool (PG-SGA©)

- Morbidity data

- Local disease recurrence data

- Overall survival data

Inclusion Criteria:

- Patient 18 or older.

- Patient diagnosed with a metastatic tumor of the spine

- Informed consent obtained, i.e.:

- Ability to understand the content of the patient information/ICF

- Willingness and ability to participate in the registry according to the Registry
Plan

- Signed and dated EC/IRB approved written informed consent (if consent is required
by the EC/ IRB at the registry site)

Exclusion Criteria:

• Patient diagnosed with a primary tumor of the spine.