Effects of Exercise and Energy Balance on 24-hour Blood Glucose Control
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 1/23/2019 |
| Start Date: | October 21, 2016 |
| End Date: | November 2024 |
The study team will assess "free-living" 24h glucose control using continuous glucose
monitors (CGM) over an 88h period on two separate occasions. Importantly, standardized meals
will be provided and will be consumed at specific times each day of the CGM measurement
period. These meals will be identical on day 1 and day 3 of measurement. Each subject will
complete two CGM periods, which will be identical except for the calorie and macronutrient
content of the post-exercise dinner. In addition, during trial 1, two CGM's will be worn,
while only 1 CGM will be worn on trial 2.
monitors (CGM) over an 88h period on two separate occasions. Importantly, standardized meals
will be provided and will be consumed at specific times each day of the CGM measurement
period. These meals will be identical on day 1 and day 3 of measurement. Each subject will
complete two CGM periods, which will be identical except for the calorie and macronutrient
content of the post-exercise dinner. In addition, during trial 1, two CGM's will be worn,
while only 1 CGM will be worn on trial 2.
Subjects will be instructed to exercise exactly 2 days before each experimental trial period,
and then abstain from exercise other than the exercise session on Day 2 of the trial period
until after the trial period is complete.
Subjects will arrive to the Substrate Metabolism Laboratory at approximately 4pm on Day 0 of
each trial. For trial 1, two CGM devices will be placed on either side of the abdomen, near
the belly button. For trial 2, only one CGM device will be placed on one side of the abdomen.
On Day 1 of both trials, participants will go about their normal daily activities (other than
planned exercise) while eating provided meals at designated time points. This day will serve
as the non-exercise control day.
On Day 2, subjects will return to the laboratory to exercise on the bike for ~1h at a
moderate exercise intensity (approximately 65% of their measured VO2peak) to expend 350
kilocalories. During trial 1 only, subjects will use the mouthpiece and nose clip (which will
allow all of their expired air to pass through the metabolic cart for analysis of oxygen
consumption and carbon dioxide production) for ~5 min at the beginning, middle and toward the
end of exercise to verify they are exercising at 65% of VO2peak. This will also allow the
study team to accurately measure energy expenditure (kcal) during exercise. On trial 2,
subjects will perform the exact same exercise protocol, but the mouthpiece and nose clip will
not be required. One hour after the exercise session, participants will eat their
standardized dinner. Importantly, the caloric content of this meal will differ between the
two trials (+/- 350kcal), and this will be the only difference between the two study trial
periods.
On Day 3, participants will go about their normal daily activities (other than planned
exercise) while eating the provided meals at designated time points. This day will serve as
the post-exercise day.
On Day 4, participants will return to the laboratory at approximately 8am for removal of the
CGM device(s).
and then abstain from exercise other than the exercise session on Day 2 of the trial period
until after the trial period is complete.
Subjects will arrive to the Substrate Metabolism Laboratory at approximately 4pm on Day 0 of
each trial. For trial 1, two CGM devices will be placed on either side of the abdomen, near
the belly button. For trial 2, only one CGM device will be placed on one side of the abdomen.
On Day 1 of both trials, participants will go about their normal daily activities (other than
planned exercise) while eating provided meals at designated time points. This day will serve
as the non-exercise control day.
On Day 2, subjects will return to the laboratory to exercise on the bike for ~1h at a
moderate exercise intensity (approximately 65% of their measured VO2peak) to expend 350
kilocalories. During trial 1 only, subjects will use the mouthpiece and nose clip (which will
allow all of their expired air to pass through the metabolic cart for analysis of oxygen
consumption and carbon dioxide production) for ~5 min at the beginning, middle and toward the
end of exercise to verify they are exercising at 65% of VO2peak. This will also allow the
study team to accurately measure energy expenditure (kcal) during exercise. On trial 2,
subjects will perform the exact same exercise protocol, but the mouthpiece and nose clip will
not be required. One hour after the exercise session, participants will eat their
standardized dinner. Importantly, the caloric content of this meal will differ between the
two trials (+/- 350kcal), and this will be the only difference between the two study trial
periods.
On Day 3, participants will go about their normal daily activities (other than planned
exercise) while eating the provided meals at designated time points. This day will serve as
the post-exercise day.
On Day 4, participants will return to the laboratory at approximately 8am for removal of the
CGM device(s).
Inclusion criteria
- Age: 18-40
- Body Mass Index: 20-30 kg/m2
Exclusion criteria
- Pregnant or lactating
- Evidence/history of cardiovascular or metabolic disease
- Medications known to affect glucose metabolism
We found this trial at
1
site
500 S State St
Ann Arbor, Michigan 48109
Ann Arbor, Michigan 48109
(734) 764-1817
Principal Investigator: Jeff F Horowitz
University of Michigan The University of Michigan was founded in 1817 as one of the...
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