Effect of Valdecoxib Pretreatment on Pain and Secondary Hyperalgesia in Healthy Volunteers
| Status: | Completed |
|---|---|
| Conditions: | Chronic Pain, Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 11/25/2017 |
| Start Date: | August 2004 |
| End Date: | April 2006 |
Effect of Valdecoxib Pretreatment on Pain and Secondary Hyperalgesia: a Randomized Controlled Trial in Healthy Volunteers
Tis study was designed to test the hypothesis that pretreatment with valdecoxib, prior to
injury could reduce or prevent the development of secondary hyperalgesia around the area of
primary injury. A heat/capsaicin model of induced hyperalgesia was tested in healthy
volunteers in a randomized, double blind, cross-over trial of a single dose of 40 mg
vadecoxib versus control. Subjects rated pain intesnsity and unpleasantness following heat
stimulation of the forearm, the area of hyperalgesia was also mapped over the course of the
experiment.
injury could reduce or prevent the development of secondary hyperalgesia around the area of
primary injury. A heat/capsaicin model of induced hyperalgesia was tested in healthy
volunteers in a randomized, double blind, cross-over trial of a single dose of 40 mg
vadecoxib versus control. Subjects rated pain intesnsity and unpleasantness following heat
stimulation of the forearm, the area of hyperalgesia was also mapped over the course of the
experiment.
Inclusion Criteria:
- healthy male of non-pregnant female; 18yo or older
- not currently taking NSAID
- able and willing to provide informed consent
- willing to avoid other NSAIDs in 24 hour period following study
- no known hypersentitivites or contraindications to NSAIDS, sulfonomides or capsaicin
Exclusion Criteria:
- pregnant or breast feeding
- use of NSAIDS or other analgesic medications in past 7 days
- unwilling or unable to give informed consent
- contraindication to any study medication or other NSAID
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