Structural and Molecular Neuroplasticity in Migraine



Status:Completed
Conditions:Migraine Headaches
Therapuetic Areas:Neurology
Healthy:No
Age Range:18 - 45
Updated:11/25/2017
Start Date:January 2011
End Date:October 2014

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The main purpose of this study is to integrate novel MRI techniques with positron emission
tomography(PET) for the study of structural and molecular neuroplasticity in the brain of
migraineurs, and its clinical association with changes in pain perception and modulation
(e.g. allodynia). We will attempt to acquire images of the brain that may, in the future,
assist doctors in better understanding how pain is felt and regulated in migraine sufferers.

To investigate interictal opioid receptor (MOR) binding potential (BPND) changes in
migraineurs as compared to age/gender-matched healthy controls. To demonstrate that frequency
of the headache attacks and severity of cutaneous allodynia levels in migraineurs experienced
over multiple attacks are correlated with levels of MOR BPND in specific brain regions. To
investigate whether dysfunction of the pain regulatory endogenous opioid system of
migraineurs is correlated with changes in the gray matter thickness in cortical areas
associated with pain perception and modulation.

Inclusion Criteria:

- Between 18-45 years of age

- Between 1-14 migraine attacks per month or healthy

Exclusion Criteria:

- Cannot be taking daily migraine medication

- Healthy subjects cannot be taking hormonal birth control pills or other medication

- Cannot have chronic pain or a neurologic/psychiatric disorder such as: multiple
sclerosis and bipolar disorder.
We found this trial at
1
site
194
mi
from 16510
Ann Arbor, MI
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