Diagnostic Accuracy of Multislice CT Angiography for Acute Chest Pain
| Status: | Completed |
|---|---|
| Conditions: | Angina, Cardiology, Cardiology, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 30 - Any |
| Updated: | 11/29/2017 |
| Start Date: | July 2006 |
| End Date: | September 2009 |
Diagnostic Accuracy of Multislice CT Angiography for Acute Chest Pain - Assessment of Chest Pain Utilizing a Triple Rule Out Evaluation With Computed Tomography (ACUTE CT) Trial
The ACUTE CT trial is designed to test whether the assessment of chest structures by
high-resolution multislice computed tomography (CT) provides equivalent diagnostic accuracy
for patient with acute chest pain or other potential cardiac symptoms as compared to a
standard of care evaluation.
high-resolution multislice computed tomography (CT) provides equivalent diagnostic accuracy
for patient with acute chest pain or other potential cardiac symptoms as compared to a
standard of care evaluation.
Adults at low to intermediate risk of acute coronary syndrome who present to the Emergency
Department with symptoms suggestive of cardiac ischemia will undergo a blinded cardiac CT
followed by a standard of care (SOC) strategy. Significant coronary artery disease on CT
(coronary stenosis >50%) will be compared to an adjudicated diagnosis derived from clinical
data and other diagnostic tests based on the SOC strategy. Costs for the SOC evaluation will
be collected and compared to a CT-based evaluation. Patients will be followed for 3 years
after enrollment to evaluate prognosis.
Department with symptoms suggestive of cardiac ischemia will undergo a blinded cardiac CT
followed by a standard of care (SOC) strategy. Significant coronary artery disease on CT
(coronary stenosis >50%) will be compared to an adjudicated diagnosis derived from clinical
data and other diagnostic tests based on the SOC strategy. Costs for the SOC evaluation will
be collected and compared to a CT-based evaluation. Patients will be followed for 3 years
after enrollment to evaluate prognosis.
Inclusion Criteria:
- Low to intermediate risk of angina with a TIMI ACS Risk Score ≤ 4
- chest pain or other symptoms suggestive of ACS within 24 hours
- male ≥30 years or female ≥45 years old
- at least one cardiac risk factor
- no obvious cause for symptoms.
Exclusion Criteria:
- known CAD
- ST segment elevation, new left bundle branch block or dynamic ECG changes
- creatinine ≥1.8 g/dL
- pregnant or lactating female
- hemodynamic or respiratory instability
- ongoing bronchospasm
- known iodinated contrast allergy
- atrial fibrillation or irregular heart rate
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