A Study Examining Adolescents With Non-Suicidal Self-Injury

This study is designed to study brain development in 12-14 year old females with a history of
NSSI. Assessments will take place over the course of three years, with three visits per year
- a total of nine visits.

The first visit will take place at the Ambulatory Research Center (ARC) at the Fairview
Riverside hospital complex. This visit will include a number of questionnaires designed to
gather information about the participant's physical and psychological health. Additionally,
measures of intelligence quotient (IQ) and demographics will be assessed.

The second visit will again take place at the ARC. For this visit, participants will be asked
to partake in the Trier Social Stress Test (TSST) in which they prepare a short, five-minute
speech and deliver the speech to an audience with an additional task to follow. The TSST will
be videotaped. Following the completion of this task, the participant will complete computer
tests in order to measure things like attention and memory. During the second visit, five
saliva samples will be collected to measure levels of the hormone Cortisol. The participant
will need to collect additional saliva samples at home.

The third visit will take place at the University of Minnesota Center for Magnetic Resonance
Research (CMRR) and will involve a brain MRI. Before the MRI the participant will be asked to
provide a urine sample and complete a drug and pregnancy test. During the MRI, the
participant will be asked to lie quietly in the scanner. The participant will do activities
such as resting, listening to music, and playing games using a button box while in the
scanner.

The participant will need to come in to complete these assessments twice more at one and two
years following the completion of the first set of visits - a total of nine visits overall.

Inclusion Criteria:

- 12-16 years old

- Female

- Has had first menstruation

- Willingness to have de-identified data shared with RDoC database

Inclusion Criteria - Adolescents with Non-Suicidal Self-Injury:

- Any history of self harm

Inclusion Criteria - Healthy Controls:

- No history of self harm

Exclusion Criteria:

- Male

- Pregnancy

- MRI Incompatibility

- IQ of less than 80

- Major Medical Illness

- Diagnosis of any of the following: Primary Psychotic Disorder, Bipolar Spectrum
Disorder, Autism Spectrum Disorder, Current or Past Substance Use Disorder