Diabetes Study With Rosiglitazone Monotherapy Versus Metformin Or Glyburide/Glibenclamide



Status:Completed
Conditions:Diabetes, Diabetes
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:30 - 75
Updated:12/1/2017
Start Date:January 3, 2000
End Date:June 19, 2006

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Trial Summary
Trial Overview
Inclusion Criteria

A Randomized, Double-Blind Study to Compare the Durability of Glucose Lowering and Preservation of Pancreatic Beta-Cell Function of Rosiglitazone Monotherapy Compared to Metformin or Glyburide/Glibenclamide in Patients With Drug-Naive, Recently Diagnosed Type 2 Diabetes Mellitus

The study will compare and evaluate the effects of long-term treatment of monotherapy with
rosiglitazone, metformin and glyburide/glibenclamide on the improvement and maintenance of
glycemic control in patients with recently diagnosed type 2 diabetes mellitus.


Inclusion criteria:

- Newly diagnosed patients (< 3years) with type 2 diabetes.

- Fasting plasma glucose (FPG) range of 126-240 mg/dL at Screening.

- No previous treatment with oral or parenteral glucose-lowering therapy.

Exclusion criteria:

- History of lactic acidosis.

- Anemia (<11g for males, <10 g for females).

- Unstable or severe NY Heart Association-class 3 or 4.

- Any NY Heart Association congestive heart failure.

- Patients with chronic diseases requiring periodic or intermittent treatment with oral
or intravenous corticosteroids.
We found this trial at
136
sites
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Vienna,
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Albany, New York 12206
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Albuquerque, New Mexico 87109
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Ann Arbor, Michigan 48109
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Anniston, Alabama 36207
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Arlington, Texas 76014
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Atlanta, Georgia 30341
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Atlanta, GA
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Austin, Texas 78705
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Baltimore, Maryland 21201
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Bangor, Maine 04401
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Beaumont, Texas 77701
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Bend, Oregon 97701
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Berkeley, California 94704
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Billings, Montana 59102
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Birmingham, Alabama 35249
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Blue Ridge, Georgia 30513
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Boise, Idaho 83712
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Boston, Massachusetts 02115
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Boulder, Colorado 80304
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Bristol, Tennessee 37620
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Bronx, New York 10461
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Charleston, South Carolina 29425
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Charleston, West Virginia 25304
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Charlottesville, Virginia 22903
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Cherry Hill, New Jersey 08003
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Chicago, Illinois 60611
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Cincinnati, Ohio 45229
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Cleveland, Ohio 44195
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Columbia, South Carolina 29203
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Corona, California 92882
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Corpus Christi, Texas 78405
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Dallas, Texas 75230
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Denver, Colorado 80206
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Detroit, Michigan 48202
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Downingtown, Pennsylvania 19335
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Dunwoody, Georgia 30338
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Durham, North Carolina 27705
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Endwell, New York 13760
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Englewood, Colorado 80110
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Eugene, Oregon 97401
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Evansville, Indiana 47714
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Fair Oaks, California 95628
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Fayetteville, Georgia 30214
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Feasterville, Pennsylvania 19053
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Federal Way, Washington 98003
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Fleetwood, Pennsylvania 19522
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Flushing, New York 11355
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Fort Myers, Florida 33916
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Fort Worth, Texas 76104
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Fremont, California 94538
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Fresno, California 93720
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Fullerton, California 92835
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Greenbrae, California 94904
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Greer, South Carolina 29651
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Gurnee, Illinois 60031
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Harbor City, California 90710
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Healdsburg, California 95448
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Henderson, Nevada 89052
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Hermitage, Pennsylvania 16148
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Hershey, Pennsylvania 17033
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Hollywood, Florida 33021
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Honolulu, Hawaii 96813
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Houston, Texas 77030
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Huntington, West Virginia 25701
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Indianapolis, Indiana 46202
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Irving, Texas 75039
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Jackson, Mississippi 39202
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Jacksonville, Florida 32207
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Jefferson Hills, Pennsylvania 15025
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Kansas City, Missouri 64128
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La Jolla, California 92093
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Lake Charles, Louisiana 70601
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Lansing, Michigan 48917
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Lexington, Kentucky 40504
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Little Rock, Arkansas 72205
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Loma Linda, California 92357
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Longmont, Colorado 80501
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Los Angeles, California 90025
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Madison, Wisconsin 53792
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Melbourne, Florida 32935
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Mesa, Arizona 85206
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Miami, Florida 33136
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Midland, Texas 79701
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Milwaukee, Wisconsin 53215
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Minneapolis, Minnesota 55404
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Modesto, California 95350
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Mogadore, Ohio 44260
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Nashville, Tennessee 37203
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New Orleans, Louisiana 70112
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New York, New York 10032
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Newport News, Virginia 23606
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Ogden, Utah 84403
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Oklahoma City, Oklahoma 73112
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Olive Branch, Mississippi 38654
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Omaha, Nebraska 68131
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Oregon, Wisconsin 53575
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Orlando, Florida 32806
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Palm Harbor, Florida 34684
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Pasadena, California 91105
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Philadelphia, Pennsylvania 19104
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Pittsburgh, Pennsylvania 15213
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