Functional Brain Imaging and Employment in First-Episode Psychotic Patients Treated With Risperdal

First episode patients have a greater potential for therapeutic response than multi-episode
patients, and many of them also havea great desire to rejoin the workforce. Unfortunately,
first episode patients become non-compliant or intermittently compliant with prescribed
antipsychotic treatment at least as frequently as multi-episode patients. We believe that
assured treatment with Risperal CONTSTA will provide first episode patients wiwth their best
opporutnity for continued improvement in cognitive function beyond 3 months of treatment and
that improvements in cognitive function will be associated with a greater likelihood of
employment, real-world outcomes, such as independent living, as well as measures of brain
function.

Inclusion Criteria:

- male or female between 18-40 years of age

- meet DSM-IV criteria for first-episode schizophreniform, schizophrenia or
schizoaffective disorder

Exclusion Criteria:

- pregnant & breast-feeding women

- patients with known sensitivity to oral Risperdal