Pre-medication With Alfentanil vs Placebo During ECT
| Status: | Recruiting |
|---|---|
| Conditions: | High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 12/26/2018 |
| Start Date: | June 4, 2018 |
| End Date: | December 2019 |
| Contact: | Quinn McCutchen, MD |
| Email: | tmccutch@wakehealth.edu |
| Phone: | 336-716-4498 |
Effects of Pre-medication With Alfentanil on Hemodynamics During and Immediately Following Electroconvulsive Therapy (ECT)
Hemodynamic changes associated with the conduct of electroconvulsive therapy may be minimized
with the administration of alfentanil as part of their anesthetic regimen. This study
proposes to compare the effects in a blinded fashion. Currently alfentanil is an FDA approved
drug used on a daily basis by anesthesiologists on other surgeries so this is not a new
indication.
with the administration of alfentanil as part of their anesthetic regimen. This study
proposes to compare the effects in a blinded fashion. Currently alfentanil is an FDA approved
drug used on a daily basis by anesthesiologists on other surgeries so this is not a new
indication.
Electroconvulsive therapy is associated with brief hemodynamic alterations that in some
patients may be well outside the range of normalcy and potentially dangerous to the patient
(Duma A, et al). This cardiovascular response is caused by activation of the autonomic
nervous system and consists of an initial parasympathetic response rapidly followed by
sympathetically mediated tachycardia and hypertension. The ultra-short acting synthetic
opioid alfentanil has a rapid onset and duration of action that mirrors the duration of
hemodynamic perturbation associated with ECT while having minimal or no effect on the
duration or quality of the seizure. This drug may be effective in blunting the hemodynamic
perturbations associated with ECT with a minimal amount of side effects.
patients may be well outside the range of normalcy and potentially dangerous to the patient
(Duma A, et al). This cardiovascular response is caused by activation of the autonomic
nervous system and consists of an initial parasympathetic response rapidly followed by
sympathetically mediated tachycardia and hypertension. The ultra-short acting synthetic
opioid alfentanil has a rapid onset and duration of action that mirrors the duration of
hemodynamic perturbation associated with ECT while having minimal or no effect on the
duration or quality of the seizure. This drug may be effective in blunting the hemodynamic
perturbations associated with ECT with a minimal amount of side effects.
Inclusion Criteria:
- Age > /=18 years
- Males or females
- Anticipating electroconvulsive therapy to treat refractory depressive disorder
Exclusion Criteria:
- Under the age of 18
- Allergy to alfentanil
- Allergy to other standard anesthetic medications utilized in the course of ECT
(glycopyrrolate, methohexital, and succinylcholine)
- History of malignant hyperthermia
- History of severe airway obstruction, bronchospasm or laryngospasm
- History of recent myocardial infarction, ventricular arrhythmia
- Adverse reaction to ECT requiring premedication with lidocaine or atropine
- Non-English speaking
- Patients unable to consent for themselves
- Current pregnancy
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