A Study of LY3381916 Alone or in Combination With LY3300054 in Participants With Solid Tumors



Status:Recruiting
Conditions:Lung Cancer, Prostate Cancer, Cancer, Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/5/2019
Start Date:February 21, 2018
End Date:February 18, 2022
Contact:There may be multiple sites in this clinical trial. 1-877-CTLILLY (1-877-285-4559) or
Email:clinicaltrials.gov@lilly.com
Phone:1-317-615-4559

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase 1a/1b Study of an Anti-IDO-1 Agent (LY3381916) Administered Alone or in Combination With Anti- PD-L1 Checkpoint Antibody (LY3300054) in Solid Tumors

The purpose of this study is to evaluate the safety of the study drug LY3381916 administered
alone or in combination with anti-programmed cell death ligand 1 (PD-L1) checkpoint antibody
(LY3300054).


Inclusion Criteria:

- Participant must have histological or cytological evidence of a diagnosis of cancer
that is advanced and/or metastatic.

- Have adequate organ function.

- Have a performance status (PS) of ≤1 on the Eastern Cooperative Oncology Group (ECOG)
scale.

- Have discontinued previous treatments for cancer.

- Are able to swallow capsules.

Exclusion Criteria:

- Currently enrolled in a clinical study.

- Have a serious concomitant systemic disorder.

- Have a symptomatic human immunodeficiency virus infection or symptomatic
activated/reactivated hepatitis B or C.

- Have a significant cardiac condition.

- Have previously received an indoleamine- 2,3-dioxygenase (IDO) inhibitor.
We found this trial at
4
sites
Sarah Cannon Research Institute (SCRI)
Nashville, Tennessee 37203
Principal Investigator: SMO Sarah Cannon Research Inst.
Phone: 615-329-7615
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Institut Jules Bordet
121 Boulevard de Waterloo
Brussel, 1000
Principal Investigator: Nuria Kotecki
Phone: 3225413059
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Brussel,
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IU Simon Cancer Center
Indianapolis, Indiana 46202
Principal Investigator: Bert H O'Neil
Phone: 317-278-8845
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Indianapolis, IN
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Tennessee Oncology, PLLC
250 25th Ave N, Ste 100
Nashville, Tennessee 37023
615-320-5090
Principal Investigator: Johanna Chock Bendell
Phone: 6153297274
Tennessee Oncology, PLLC Since 1976 Tennessee Oncology has been providing quality cancer care. In 2013,...
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