Cognitive Training and tDCS for Children With FASD
| Status: | Recruiting |
|---|---|
| Conditions: | Women's Studies |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 10 - 16 |
| Updated: | 3/27/2019 |
| Start Date: | November 20, 2017 |
| End Date: | June 30, 2019 |
| Contact: | Jeffrey R Wozniak, Ph.D. |
| Email: | jwozniak@umn.edu |
| Phone: | 612-273-9741 |
Neuromodulation Augmented Cognitive Remediation to Improve Executive Dysfunction in Fetal Alcohol Spectrum Disorder (FASD)
This is a randomized placebo-controlled trial of cognitive training with transcranial direct
current stimulation (tDCS) for children and adolescents (ages 10 - 16 years) with prenatal
alcohol exposure (PAE).
current stimulation (tDCS) for children and adolescents (ages 10 - 16 years) with prenatal
alcohol exposure (PAE).
Prenatal alcohol exposure (PAE) has profound detrimental effects on brain development and, as
a result, has permanent consequences for cognition, learning, and behavior. Individuals with
Fetal Alcohol Spectrum Disorders (FASD) commonly have a range of neurocognitive impairments
that directly lead to practical problems with learning, attention, working memory, task
planning/execution, and decision making, among other areas of functioning. Despite the
profound public health burden posed by FASD, there have been very few treatment studies in
this population. This study will examine the effects of a cognitive remediation training
augmented with tDCS in children and adolescents with PAE. Functional magnetic resonance
imaging will be collected to provide preliminary data of brain circuitry changes created by
this intervention. The study involves a baseline visit with cognitive testing, MRI, 5
sessions of tDCS (including the baseline visit), and a 6th visit for cognitive testing and
MRI. All sessions will be completed within a 28 to 56 day time window.
a result, has permanent consequences for cognition, learning, and behavior. Individuals with
Fetal Alcohol Spectrum Disorders (FASD) commonly have a range of neurocognitive impairments
that directly lead to practical problems with learning, attention, working memory, task
planning/execution, and decision making, among other areas of functioning. Despite the
profound public health burden posed by FASD, there have been very few treatment studies in
this population. This study will examine the effects of a cognitive remediation training
augmented with tDCS in children and adolescents with PAE. Functional magnetic resonance
imaging will be collected to provide preliminary data of brain circuitry changes created by
this intervention. The study involves a baseline visit with cognitive testing, MRI, 5
sessions of tDCS (including the baseline visit), and a 6th visit for cognitive testing and
MRI. All sessions will be completed within a 28 to 56 day time window.
Inclusion Criteria:
- Documented heavy prenatal alcohol exposure (self-report, social service records, or
adoption records) and meeting criteria for an associated FASD diagnosis (FAS, partial
FAS, or ARND).
- An available parent or legal guardian capable of giving informed consent
Exclusion Criteria:
- Substance abuse in the participant
- Neurological condition or other developmental disorder
- Serious psychiatric disorder known to affect brain functioning and cognitive
performance
- Birthweight < 1500 grams
- MRI contraindication
- tDCS contraindication
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