Study Evaluating Inotuzumab Ozogamicin (CMC-544) Plus Rituximab In Diffuse Large B-Cell Non-Hodgkin's Lymphoma



Status:Completed
Conditions:Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:12/7/2017
Start Date:June 8, 2009
End Date:October 31, 2012

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Trial Summary
Trial Overview
Inclusion Criteria

An Open-label, Single-arm, Phase 2 Study Of Inotuzumab Ozogamicin Plus Rituximab In Subjects With Relapsed/Refractory Cd22-positive Diffuse Large B-cell Lymphoma, Eligible For Autologous Stem Cell Transplantation

The purpose of this study is to evaluate inotuzumab ozogamicin in combination with rituximab
prior to an autologous stem cell transplant (aSCT) in patients with relapsed/refractory
diffuse large B-cell Non-Hodgkin's lymphoma.


Inclusion Criteria:

- CD20/CD22-positive diffuse large B-cell NHL that has relapsed after 1 or 2 prior
therapies; one prior therapy must include anthracyclines and one must include
rituximab in combination with chemotherapy

- Relapsed/disease progression within 12 months after start of prior therapy and/or
secondary International Prognostic Index (sIPI) score greater than 1

- Eligible for autologous stem cell transplant (aSCT)

Exclusion Criteria:

- Prior allogeneic hematopoietic stem cell transplant

- Within 6 months prior to test article: autologous transplant, treatment with anti-CD22
antibodies, radio-immunotherapy

- Veno-occlusive disease or sinusoidal obstruction syndrome, chronic liver disease,
systemic vasculitides, current or chronic hepatitis B or C infection
We found this trial at
20
sites
University of Texas M.D. Anderson Cancer Center
1515 Holcombe Blvd
Houston, Texas 77030
 713-792-2121
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
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Houston, TX
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Tufts Medical Center
800 Washington St
Boston, Massachusetts 02111
(617) 636-5000
Tufts Medical Center Tufts Medical Center is an internationally-respected academic medical center – a teaching...
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Boston, MA
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University of Michigan Comprehensive Cancer Center
1500 East Medical Center Drive
Ann Arbor, Michigan 48109
800-865-1125
University of Michigan Comprehensive Cancer Center The U-M Comprehensive Cancer Center's mission is the conquest...
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Ann Arbor, MI
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UT Southwestern University Hospital - St. Paul
Dallas, Texas 75235
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Dallas, TX
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Zale Lipshy University Hospital
Dallas, Texas 75235
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Dallas, TX
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U.T. Southwestern Medical Center
2201 Inwood Rd
Dallas, Texas 75235
(214) 645-8300
U.T. Southwestern Medical Center The story of UT Southwestern Medical Center is one of commitment...
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Dallas, TX
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John Theurer Cancer Center (JTCC) at Hackensack University Medical Center (HUMC)
92 2nd Street
Hackensack, New Jersey 07601
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Hackensack, NJ
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Hackensack University Medical Center
30 Prospect Ave
Hackensack, New Jersey 07601
(201) 996-2000
Hackensack University Medical Center Hackensack University Medical Center, part of the Hackensack University Health Network,...
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Hackensack, NJ
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John Theurer Cancer Center at the Hackensack University Medical Center
92 2nd St
Hackensack, New Jersey 07601
(201) 996-5900
John Theurer Cancer Center at the Hackensack University Medical Center The mission of the John...
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Hackensack, NJ
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Penn State Milton S. Hershey Medical Center
500 University Dr
Hershey, Pennsylvania 17033
(717) 531-6955
Penn State Milton S. Hershey Medical Center Penn State Milton S. Hershey Medical Center, Penn...
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Hershey, PA
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The University of Texas M. D. Anderson Cancer Center
Houston, Texas 77030
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Houston, TX
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CHRU de Lille Hopital Claude Huriez
Lille, 59037
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Lille,
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Pharmaceutical Research Center
600 Highland Avenue
Madison, Wisconsin 53792
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Madison, WI
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University of Wisconsin Hospital and Clinics
600 Highland Ave
Madison, Wisconsin 53792
(608) 263-6400
University of Wisconsin Hospital and Clinics UW Health strives to meet the health needs of...
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Madison, WI
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Loyola University Medical Center, Foster G. McGraw Hospital and Satellites
Maywood, Illinois 60153
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Maywood, IL
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Memorial Sloan Kettering Cancer Center
1275 York Ave
New York, New York 10021
(212) 639-2000
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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New York, NY
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Barnes Jewish Hospital
Saint Louis, Missouri 63110
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Saint Louis, MO
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Washington University School of Medicine
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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Saint Louis, MO
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Siteman Cancer Center
150 Entranceway Drive
Saint Peters, Missouri 63376
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Saint Peters, MO
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Methodist Healthcare System of
8109 Fredericksburg Road
San Antonio, Texas 78229
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San Antonio, TX
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