ZIMURA in Combination With LUCENTIS in Patients With Neovascular Age Related Macular Degeneration (NVAMD)



Status:Completed
Conditions:Ocular
Therapuetic Areas:Ophthalmology
Healthy:No
Age Range:50 - Any
Updated:11/17/2018
Start Date:October 11, 2017
End Date:October 18, 2018

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A Phase 2A Open-label Trial to Assess the Safety of ZIMURA™ (Anti-C5) Administered in Combination With LUCENTIS® 0.5 mg in Treatment Naive Subjects With Neovascular Age Related Macular Degeneration

To assess the safety of intravitreal Zimura™ (complement factor C5 inhibitor) administered in
combination with Lucentis® 0.5 mg in treatment naïve subjects with neovascular age related
macular degeneration (NVAMD)


Inclusion Criteria:

- Active subfoveal NVAMD

Exclusion Criteria:

- History or evidence of severe cardiac disease

- Any major surgical procedure within one month of trial entry

- Subjects with a clinically significant laboratory value

- Any treatment with an investigational agent in the past 60 days for any condition

- Women who are pregnant or nursing

- Known serious allergies to the fluorescein dye used in angiography, povidone iodine,
to the components of the ranibizumab formulation, or to the components of the Zimura
formulation

- Any prior treatment for AMD other than oral supplements of vitamins and minerals
We found this trial at
24
sites
Phoenix, Arizona 85014
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Abilene, TX
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Altamonte Springs, Florida 32701
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Altamonte Springs, FL
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Beverly Hills, California 90211
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Beverly Hills, CA
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Boston, Massachusetts 02114
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Boston, MA
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Budapest,
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Fullerton, California 92835
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Fullerton, CA
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Golden, Colorado 80401
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Golden, CO
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710 Coronado Center Drive
Henderson, Nevada 89052
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Henderson, NV
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Ladson, South Carolina 29456
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Ladson, SC
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502 East New Haven Avenue
Melbourne, Florida 32901
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Melbourne, FL
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Minneapolis, Minnesota 55435
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Minneapolis, MN
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Peoria, Illinois 61615
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Peoria, IL
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Philadelphia, Pennsylvania 19107
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Philadelphia, PA
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Portland, Oregon 97210
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Portland, OR
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Redlands, California 92374
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Redlands, CA
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Reno, Nevada 89502
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Reno, NV
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Sacramento, California 95819
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Sacramento, CA
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Santa Ana, California 92705
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Santa Ana, CA
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3107 East Genesee Street
Syracuse, New York 13224
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Syracuse, NY
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Tucson, Arizona 85704
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Tucson, AZ
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Tucson, Arizona 85710
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Tucson, AZ
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Wichita, KS
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Willow Park, Texas 76087
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Willow Park, TX
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