ZIMURA in Combination With LUCENTIS in Patients With Neovascular Age Related Macular Degeneration (NVAMD)
Status: | Completed |
---|---|
Conditions: | Ocular |
Therapuetic Areas: | Ophthalmology |
Healthy: | No |
Age Range: | 50 - Any |
Updated: | 11/17/2018 |
Start Date: | October 11, 2017 |
End Date: | October 18, 2018 |
A Phase 2A Open-label Trial to Assess the Safety of ZIMURA™ (Anti-C5) Administered in Combination With LUCENTIS® 0.5 mg in Treatment Naive Subjects With Neovascular Age Related Macular Degeneration
To assess the safety of intravitreal Zimura™ (complement factor C5 inhibitor) administered in
combination with Lucentis® 0.5 mg in treatment naïve subjects with neovascular age related
macular degeneration (NVAMD)
combination with Lucentis® 0.5 mg in treatment naïve subjects with neovascular age related
macular degeneration (NVAMD)
Inclusion Criteria:
- Active subfoveal NVAMD
Exclusion Criteria:
- History or evidence of severe cardiac disease
- Any major surgical procedure within one month of trial entry
- Subjects with a clinically significant laboratory value
- Any treatment with an investigational agent in the past 60 days for any condition
- Women who are pregnant or nursing
- Known serious allergies to the fluorescein dye used in angiography, povidone iodine,
to the components of the ranibizumab formulation, or to the components of the Zimura
formulation
- Any prior treatment for AMD other than oral supplements of vitamins and minerals
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