Research Evaluating the Value of Augmenting Medication With Psychotherapy



Status:Completed
Conditions:Depression, Depression
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:18 - 75
Updated:12/8/2017
Start Date:April 2003
End Date:March 2007

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CBASP Augmentation for Treatment of Chronic Depression

This 24-week study, with a 12-month follow up period, will compare the effectiveness of
antidepressant medication alone to the combination of psychotherapy and antidepressant
medication in patients with chronic depression.

Chronic depression affects approximately 5% of adults in the United States and is associated
with significant functional impairment and high health care utilization. The combination of
drug treatment and psychotherapy may be most effective in treating depression. This study
will determine the effects of adjunctive psychotherapy in depressed patients who have failed
to respond or have responded only partially to an initial trial medication.

Participants receive an initial trial of antidepressant medication for 8 to 12 weeks.
Participants who continue to have depressive symptoms are randomly assigned to add Cognitive
Behavioral Analysis System of Psychotherapy (CBASP) or supportive therapy to their medication
regimens or to continue pharmacotherapy alone for an additional 12 weeks. Assessments are
made at 6 and 12 months post-treatment.

Inclusion Criteria

- Major depressive episode

- Depressive symptoms > 2 years without remission

- Hamilton Depression Scale (HAM-D) score > 20

- Fluent in English

Exclusion Criteria

- Psychotic disorders, bipolar disorder, post traumatic stress disorder, obsessive
compulsive disorder, or eating disorder

- Serious, unstable, or terminal medical condition

- Axis II diagnosis of antisocial, schizotypal, or severe borderline personality
disorder

- Previous treatment with CBASP

- Previous ineffective treatment with 4 of the medication treatments used in the study

- Substance abuse

- Pregnancy

- Not willing to end other psychiatric treatment
We found this trial at
8
sites
Palo Alto, California 94304
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201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
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Atlanta, GA
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4200 Fifth Ave
Pittsburgh, Pennsylvania 15260
(412) 624-4141
University of Pittsburgh The University of Pittsburgh is a state-related research university, founded as the...
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Pittsburgh, PA
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1801 Inwood Rd
Dallas, Texas 75390
(214) 645-3300
University of Texas Southwestern Medical Center UT Southwestern is an academic medical center, world-renowned for...
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Dallas, TX
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525 East 68th Street
New York, New York 10021
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New York, NY
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100 Nicolls Road
New York, New York 11794
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New York, NY
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69 Brown Street
Providence, Rhode Island 02912
(401) 863-1000
Brown University Located in historic Providence, Rhode Island and founded in 1764, Brown University is...
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Providence, RI
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Tucson, Arizona 85721
(520) 621-2211
University of Arizona The University of Arizona is a premier, public research university. Established in...
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Tucson, AZ
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