Corneal Collagen Cross-linking for Progressive Keratoconus



Status:Completed
Conditions:Dermatology
Therapuetic Areas:Dermatology / Plastic Surgery
Healthy:No
Age Range:14 - Any
Updated:6/17/2018
Start Date:December 2007
End Date:April 2011

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Trial Summary
Trial Overview
Inclusion Criteria

Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Progressive Keratoconus

Prospective, randomized multicenter study to determine the safety and effectiveness of
performing cornea collagen cross-linking (CXL) using riboflavin and UVA light in eyes with
progressive keratoconus.

This was a sham controlled study for the first three months. Patients had one eye designated
as the study eye and were randomized to receive one of two study treatments (CXL or sham) in
their study eye. The patients were evaluated at 1, 3, 6, and 12 months. At month 3 or later
patients had the option of receiving CXL treatment in both the sham and non-study eye.

Inclusion Criteria:

- Diagnosis of keratoconus

- Documented progression over previous 24 months

- Decreased BSCVA

- Must complete all study visits

Exclusion Criteria:

- Prior corneal surgery or Intacs

- History of delayed wound healing
We found this trial at
10
sites
Ophthalmic Consultants of Long Island
Rockville Centre, New York 11570
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from
Rockville Centre, NY
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Wilmer Eye Institute, Johns Hopkins University
Baltimore, Maryland 21287
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mi
from
Baltimore, MD
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Price Vision Group
Indianapolis, Indiana 46260
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mi
from
Indianapolis, IN
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Durrie Vision
8300 College Boulevard
Kansas City, Kansas 66211
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mi
from
Kansas City, KS
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Shiley Eye Center
La Jolla, California 92093
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mi
from
La Jolla, CA
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Center for Excellence in Eye Care
Miami, Florida 33176
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mi
from
Miami, FL
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Minnesota Eye Consultants, PA
Minneapolis, Minnesota 55405
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mi
from
Minneapolis, MN
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Edward Harkness Eye Institute-Columbia University Medical Center
New York, New York 10032
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mi
from
New York, NY
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Gordon -Weiss Vision Institute
San Diego, California 91222
?
mi
from
San Diego, CA
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Cornea & Laser Eye Institute; Hersh Vision Group
Teaneck, New Jersey 07666
?
mi
from
Teaneck, NJ
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