Nurse Education in Subjects With Psoriasis Undergoing Treatment With Adalimumab

This is a phase IV randomized, prospective open label study to asses the efficacy of an
extended nurse eduction program in improving adherence to the prescribed treatment regimen in
the treatment of moderate to severe psoriasis vulgaris. Twenty subjects, male or female, ages
18 and older in good health with moderate to severe chronic plaque type psoriasis for whom
adalimumab is indicated according to the adalimumab prescribing information. All subjects
must have a negative TB skin test according to prescribing guidelines. Subjects must be
starting adalimumab for the first time, prescribed by their physician.

This is an open label trial. All subjects will be receiving adalimumab as prescribed by their
physician. Half the group will be randomized to receive the additional nurse education
program, the other half will receive the normal education materials provided by their
physician.

Inclusion Criteria:

- Subjects must be male or female, 18 years of age or greater, in good health with
moderate to severe plaque psoriasis for whom adalimumab is indicated according to the
adalimumab prescribing information.

- All subjects must have a negative TB skin test according to prescribing guidelines.

- Subjects must be starting adalimumab for the first time, prescribed by their
dermatologist.

- Must give written informed consent.

- Subject must be adult males or non-pregnant , non-lactating females.

- Female subjects of childbearing potential must state that they are using measures to
avoid conception through active means including, abstinence, oral contraceptives,
intrauterine device, Depo-Provera, Norplant, tubal ligation, or vasectomy of the
partner in a monogamous relationship.

- Subjects may not be on concomitant systemic medications for their psoriasis such as
methotrexate, acitretin, etretinate, cyclosporine, prednisone ot other biological
agents or receiving phototherapy at the baseline visit, but no specific washout of
these treatments will be required.

- There is no washout for topical medications. Stable dosing of topical medications may
be used throughout the duration of the study.

Exclusion Criteria:

- Subjects who have any skin condition or disease that may require concurrent therapy or
may confound the evaluation.

- Subjects who have a history of hypersensitivity to adalimumab or history of
hypersensitivity to any of the formulation components will be excluded from the study.

- Female subjects who are not postmenopausal for at least one year, surgically sterile
or willing to practice effective contraception during the study. Nursing mothers,
pregnant women and women planning to become pregnant while on study are to be
excluded.

- Current enrollment in any research study involving an investigational drug.

- Serious local infection or systemic infection within the three months prior to the
first dose of investigational drug.

- Treatment with another investigational drug within one month prior to study drug
administration.

- Concurrent treatment with systemic retinoids, systemic steroids, methotrexate,
cyclosporine, azathioprine, thioguanine, etanercept, efalizumab, infliximab or mofetil
or other systemic immunosuppressant agents.

- Any active or history of HIV, Hepatitis or tuberculosis