Metabolic Impact of Intermittent CPAP
| Status: | Recruiting |
|---|---|
| Conditions: | Insomnia Sleep Studies, Pulmonary |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 20 - 75 |
| Updated: | 9/30/2018 |
| Start Date: | July 2013 |
| End Date: | January 2023 |
| Contact: | Chenjuan Gu, MD |
| Email: | cgu14@jhmi.edu |
| Phone: | 410-550-1816 |
Obstructive sleep apnea is a risk factor for diabetes and cardiovascular disease, by unknown
mechanisms. The investigators hypothesize that sleep apnea changes glucose and lipid
metabolism during sleep, which over time could lead to diabetes and cardiovascular disease.
This study examines metabolic changes during sleep in patients with obstructive sleep apnea.
Patients accustomed to CPAP therapy are enrolled to undergo sleep studies, either on CPAP
therapy or after withdrawing from CPAP for 3 nights. During sleep, blood samples are obtained
so that metabolic function can be compared between sleep apnea and CPAP nights.
mechanisms. The investigators hypothesize that sleep apnea changes glucose and lipid
metabolism during sleep, which over time could lead to diabetes and cardiovascular disease.
This study examines metabolic changes during sleep in patients with obstructive sleep apnea.
Patients accustomed to CPAP therapy are enrolled to undergo sleep studies, either on CPAP
therapy or after withdrawing from CPAP for 3 nights. During sleep, blood samples are obtained
so that metabolic function can be compared between sleep apnea and CPAP nights.
Participants with a history of moderate severe sleep apnea (AHI>20) will be enrolled if
participants meet inclusion/exclusion criteria. Investigators will report to the sleep
laboratory on two nights, (1) after continuing their CPAP or (2) after discontinuing CPAP for
3 nights. The order of observation will be randomized. A standard research dinner is provided
before each study. IV's are placed so that blood can be sampled at frequent (30 min)
intervals throughout the night. In the morning after each study, a glucose tolerance test and
endothelial function study (endoPAT) are performed. Serum samples will be analyzed for
glucose, insulin, free fatty acids, triglycerides, hormones, and other metabolic biomarkers.
participants meet inclusion/exclusion criteria. Investigators will report to the sleep
laboratory on two nights, (1) after continuing their CPAP or (2) after discontinuing CPAP for
3 nights. The order of observation will be randomized. A standard research dinner is provided
before each study. IV's are placed so that blood can be sampled at frequent (30 min)
intervals throughout the night. In the morning after each study, a glucose tolerance test and
endothelial function study (endoPAT) are performed. Serum samples will be analyzed for
glucose, insulin, free fatty acids, triglycerides, hormones, and other metabolic biomarkers.
Inclusion Criteria:
- History of moderate to severe Obstructive sleep apnea (OSA) (AHI or respiratory
disturbance index (RDI)> 10).
- They must also own a CPAP machine and report the ability to tolerate sleeping with or
without CPAP during the night.
Exclusion Criteria:
- Uncontrolled hypertension with systolic blood pressure >170 or diastolic blood
pressure > 110
- Congestive heart failure
- Use of clonidine or nicotinic acid medication
- Diabetes requiring the use of insulin
- Known pregnancy, by urine testing in women of child-bearing age
- History of falling asleep while driving, near miss
- High risk occupation (pilot, commercial driver)
- Hemoglobin < 10 g/dL on point of care screening
We found this trial at
1
site
4940 Eastern Ave
Baltimore, Maryland 21224
Baltimore, Maryland 21224
(410) 550-0100
Principal Investigator: Jonathan C Jun, MD
Phone: 410-550-1816
Johns Hopkins Bayview Medical Center There is no better story in American medicine in the...
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