Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide

To evaluate effectiveness of hydrochlorothiazide prophylaxis on prophylaxis, prevention and
relapse of preeclampsia or gestational hypertension on readmission rates, need for additional
antihypertensive therapy and number of triage visits.

Inclusion Criteria:

- Maternal age ≥ 18 years and <50 years.

- Diagnosis of gestational hypertension* or preeclampsia^ at any time during pregnancy,
labor or postpartum.

- defined as isolated systolic BP of 140 mm Hg or greater, a diastolic BP of 90 mm
Hg or greater, or both) or ^ defines as new-onset hypertension plus new-onset
proteinuria, or in the absence of proteinuria, preeclampsia is diagnosed as
hypertension in association with thrombocytopenia (platelet count less than
100,000/microliter), impaired liver function (elevated blood levels of liver
transaminases to twice the normal concentration), the new development of renal
insufficiency (elevated serum creatinine greater than 1.1 mg/dL or a doubling of
serum creatinine in the absence of other renal disease), pulmonary edema, or
new-onset cerebral or visual disturbances.)

Exclusion Criteria:

- Subject requiring antihypertensive therapy at time of screening.

- Planned discharge with oral anti-hypertensive medication.

- Contraindication to hydrochlorothiazide (advanced renal failure or anuria,
hypersensitivity to sulfonamides).

- Subject not able to follow up postpartum.

- Lactose intolerance.

- Pre-gestational diabetes.